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Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery

Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently administered orally with modified-release formulations. The attainment of modified-release drugs is commonly achieved through the coprecipitation of the active principle with a biodegradable polymeric carrier in the form of micro or nanop...

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Detalles Bibliográficos
Autor principal: De Marco, Iolanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959069/
https://www.ncbi.nlm.nih.gov/pubmed/36850237
http://dx.doi.org/10.3390/polym15040954
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author De Marco, Iolanda
author_facet De Marco, Iolanda
author_sort De Marco, Iolanda
collection PubMed
description Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently administered orally with modified-release formulations. The attainment of modified-release drugs is commonly achieved through the coprecipitation of the active principle with a biodegradable polymeric carrier in the form of micro or nanoparticles. In this review, some coprecipitation studies of three highly prescribed NSAIDs (in particular, ibuprofen, ketoprofen, and diclofenac sodium) have been analyzed. The techniques employed to micronize the powder, the polymers used, and the main results have been classified according to the type of release required in different categories, such as delayed, immediate, prolonged, sustained, and targeted release formulations. Indeed, depending on the pathology to be treated, it is possible to achieve specific therapeutic objectives, ensuring that the drug is released at a higher or lower dissolution rate (if compared to conventional drugs) and/or at a different time and/or in a specific site of action.
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spelling pubmed-99590692023-02-26 Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery De Marco, Iolanda Polymers (Basel) Review Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently administered orally with modified-release formulations. The attainment of modified-release drugs is commonly achieved through the coprecipitation of the active principle with a biodegradable polymeric carrier in the form of micro or nanoparticles. In this review, some coprecipitation studies of three highly prescribed NSAIDs (in particular, ibuprofen, ketoprofen, and diclofenac sodium) have been analyzed. The techniques employed to micronize the powder, the polymers used, and the main results have been classified according to the type of release required in different categories, such as delayed, immediate, prolonged, sustained, and targeted release formulations. Indeed, depending on the pathology to be treated, it is possible to achieve specific therapeutic objectives, ensuring that the drug is released at a higher or lower dissolution rate (if compared to conventional drugs) and/or at a different time and/or in a specific site of action. MDPI 2023-02-15 /pmc/articles/PMC9959069/ /pubmed/36850237 http://dx.doi.org/10.3390/polym15040954 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Marco, Iolanda
Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery
title Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery
title_full Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery
title_fullStr Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery
title_full_unstemmed Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery
title_short Coprecipitation of Class II NSAIDs with Polymers for Oral Delivery
title_sort coprecipitation of class ii nsaids with polymers for oral delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959069/
https://www.ncbi.nlm.nih.gov/pubmed/36850237
http://dx.doi.org/10.3390/polym15040954
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