Cargando…

UPLC-MS/MS Based Identification and Quantification of a Novel Dual Orexin Receptor Antagonist in Plasma Samples by Validated SWGTOX Guidelines

Lemborexant (LEM) is a novel dual orexin receptor antagonist (DORA), recently approved for the treatment of insomnia. As with other DORAs, LEM has potential of abuse and therefore placed in Schedule IV class by the United States Drug Enforcement Administration (USDEA). In this study, a sensitive and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Iqbal, Muzaffar, Alshememry, Abdullah, Imam, Faisal, Kalam, Mohd Abul, Akhtar, Ali, Ali, Essam A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959124/ https://www.ncbi.nlm.nih.gov/pubmed/36850983 http://dx.doi.org/10.3390/toxics11020109

Ejemplares similares

UPLC–MS/MS assay for quantification of an inhibitor of kinases (Foretinib) in plasma: Application to a pharmacokinetic study in rats
por: Ezzeldin, Essam, et al.
Publicado: (2020)

Eco-Friendly UPLC–MS/MS Method for Determination of a Fostamatinib Metabolite, Tamatinib, in Plasma: Pharmacokinetic Application in Rats
por: Ezzeldin, Essam, et al.
Publicado: (2021)

Eco-Friendly, Simple, Fast, and Sensitive UPLC-MS/MS Method for Determination of Pexidartinib in Plasma and Its Application to Metabolic Stability
por: Ezzeldin, Essam, et al.
Publicado: (2022)

Development and Evaluation of Chitosan Nanoparticles for Ocular Delivery of Tedizolid Phosphate
por: Kalam, Mohd Abul, et al.
Publicado: (2022)

Fabrication and Characterization of Tedizolid Phosphate Nanocrystals for Topical Ocular Application: Improved Solubilization and In Vitro Drug Release
por: Kalam, Mohd Abul, et al.
Publicado: (2022)

Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS
por: Wu, Di, et al.
Publicado: (2018)

Validation data for the quantification of the Annonaceous acetogenin annonacin in Rat brain by UPLC-MS/MS
por: Bonneau, Natacha, et al.
Publicado: (2016)

Quantification of twenty pharmacologically active dyes in water samples using UPLC-MS/MS
por: Tkaczyk-Wlizło, Angelika, et al.
Publicado: (2022)

Perspectives of Positively Charged Nanocrystals of Tedizolid Phosphate as a Topical Ocular Application in Rabbits
por: Alshememry, Abdullah, et al.
Publicado: (2022)

Quantification of Lappaconitine in Mouse Blood by UPLC-MS/MS and Its Application to a Pharmacokinetic Study
por: Chen, Fan, et al.
Publicado: (2019)

An UPLC-MS/MS Method for Simultaneous Quantification of the Components of Shenyanyihao Oral Solution in Rat Plasma
por: Jiang, Chunbo, et al.
Publicado: (2020)

Pharmacokinetic and Metabolism Studies of 12-Riboside-Pseudoginsengenin DQ by UPLC-MS/MS and UPLC-QTOF-MS(E)
por: Wang, Zhenzhou, et al.
Publicado: (2018)

Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study
por: Mei, Yi-Bin, et al.
Publicado: (2019)

Highly sensitive quantification of pemetrexed in human plasma using UPLC‐MS/MS to support microdosing studies
por: van Ewijk‐Beneken Kolmer, Eleonora W. J., et al.
Publicado: (2021)

Pharmacokinetics and metabolism of icaritin in rats by UPLC‐MS/MS
por: Huang, Zhen‐Wu, et al.
Publicado: (2019)

An Ultrafast UPLC–MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib
por: Attwa, Mohamed W., et al.
Publicado: (2023)

Rapid, Validated UPLC-MS/MS Method for Determination of Glibenclamide in Rat Plasma
por: Alam, Mohd Aftab, et al.
Publicado: (2018)

UPLC-ESI-MRM/MS for Absolute Quantification and MS/MS Structural Elucidation of Six Specialized Pyranonaphthoquinone Metabolites From Ventilago harmandiana
por: Limjiasahapong, Suphitcha, et al.
Publicado: (2021)

UPLC-MS/MS Identification and Quantification of Withanolides from Six Parts of the Medicinal Plant Datura Metel L.
por: Yang, Shi Hui, et al.
Publicado: (2020)

Development of a UPLC-MS/MS Method for the Quantification of VS-5584 and Its Application in Pharmacokinetic Studies in Rats
por: Zhou, Chunling, et al.
Publicado: (2020)

Quantification of Zonisamide in Dried Blood Spots and Dried Plasma Spots by UPLC–MS/MS: Application to Clinical Practice
por: Rmandić, Milena, et al.
Publicado: (2022)

Development and validation of an UPLC-ESI-MS/MS method for quantification of duvelisib in plasma: application to pharmacokinetic study in rats
por: Darwish, Ibrahim A., et al.
Publicado: (2023)

Development of a robust UPLC-MS/MS method for the quantification of riluzole in human plasma and its application in pharmacokinetics
por: Sun, Zhuo, et al.
Publicado: (2023)

Erratum to “Rapid, Validated UPLC-MS/MS Method for Determination of Glibenclamide in Rat Plasma”
por: Alam, Mohd Aftab, et al.
Publicado: (2019)

Assessment of biological activity and UPLC–MS based chromatographic profiling of ethanolic extract of Ochradenus arabicus
por: Ali, M. Ajmal, et al.
Publicado: (2016)

Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood
por: Shao, Lingjiu, et al.
Publicado: (2018)

UPLC–MS/MS Identification of Sterol Sulfates in Marine Diatoms
por: Nuzzo, Genoveffa, et al.
Publicado: (2018)

Toxicokinetics of 11 Gelsemium Alkaloids in Rats by UPLC-MS/MS
por: Shen, Xiuwei, et al.
Publicado: (2020)

Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS
por: Li, Ming, et al.
Publicado: (2022)

Residue Depletion of Imidocarb in Bovine Tissues by UPLC-MS/MS
por: Tang, Yaoxin, et al.
Publicado: (2022)

Characterization and quantification of flavonoid glycosides in the Prunus genus by UPLC-DAD-QTOF/MS
por: Jang, Ga Hee, et al.
Publicado: (2018)

Validated UPLC-MS/MS method for the quantification of dasatinib in plasma: Application to pharmacokinetic interaction studies with nutraceuticals in Wistar rats
por: Maher, Hadir M., et al.
Publicado: (2018)

A New UPLC-MS/MS Method Validated for Quantification of Jervine in Rat Plasma and the Study of Its Pharmacokinetics in Rats
por: Chen, Lianguo, et al.
Publicado: (2019)

Characterization and Quantification of Polyphenols and Triterpenoids in Thinned Young Fruits of Ten Pear Varieties by UPLC-Q TRAP-MS/MS
por: Sun, Liqiong, et al.
Publicado: (2019)

Sensitive Quantification of Cannabinoids in Milk by Alkaline Saponification–Solid Phase Extraction Combined with Isotope Dilution UPLC–MS/MS
por: Wei, Binnian, et al.
Publicado: (2016)

Rapid and Simultaneous Quantification of Five Quinolizidine Alkaloids in Lupinus angustifolius L. and Its Processed Foods by UPLC–MS/MS
por: Hwang, In Min, et al.
Publicado: (2020)

Simultaneous Determination and Quantification of Triterpene Saponins from Camellia sinensis Seeds Using UPLC-PDA-QTOF-MS/MS
por: Wu, Xuejin, et al.
Publicado: (2019)

Development of Simple Analytical Method for B-Group Vitamins in Nutritional Products: Enzymatic Digestion and UPLC-MS/MS Quantification
por: Nguyen, Quang Huy, et al.
Publicado: (2021)

Development and Validation of a UPLC-MS/MS Method for the Quantification of Components in the Ancient Classical Chinese Medicine Formula of Guyinjian
por: Ge, Nan, et al.
Publicado: (2022)

Simple, sensitive and rapid determination of linifanib (ABT-869), a novel tyrosine kinase inhibitor in rat plasma by UHPLC-MS/MS
por: Iqbal, Muzaffar, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fo8nmqipf3vqn8ehg68ju6v8iq