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Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry
Background: Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI). Methods: Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients o...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959358/ https://www.ncbi.nlm.nih.gov/pubmed/36836550 http://dx.doi.org/10.3390/jpm13020316 |
| _version_ | 1784895256204935168 |
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| author | Martelli, Eugenio Zamboni, Matilde Sotgiu, Giovanni Saderi, Laura Federici, Massimo Sangiorgi, Giuseppe M. Puci, Mariangela V. Martelli, Allegra R. Messina, Teresa Frigatti, Paolo Borrelli, Maria Pia Ruotolo, Carlo Ficarelli, Ilaria Rubino, Paolo Pezzo, Francesco Carbonari, Luciano Angelini, Andrea Galeazzi, Edoardo Di Pinto, Luca Calia Fiore, Franco M. Palmieri, Armando Ventoruzzo, Giorgio Mazzitelli, Giulia Ragni, Franco Bozzani, Antonio Forliti, Enzo Castagno, Claudio Volpe, Pietro Massara, Mafalda Moniaci, Diego Pagliasso, Elisa Peretti, Tania Ferrari, Mauro Troisi, Nicola Modugno, Piero Maiorano, Maurizio Bracale, Umberto M. Panagrosso, Marco Monaco, Mario Giordano, Giovanni Natalicchio, Giuseppe Biello, Antonella Celoria, Giovanni M. Amico, Alessio Di Bartolo, Mauro Martelli, Massimiliano Munaó, Roberta Razzano, Davide Colacchio, Giovanni Bussetti, Francesco Lanza, Gaetano Cardini, Antonio Di Benedetto, Bartolomeo De Laurentis, Mario Taurino, Maurizio Sirignano, Pasqualino Cappiello, Pierluigi Esposito, Andrea Trimarchi, Santi Romagnoli, Silvia Padricelli, Andrea Giudice, Giorgio Crinisio, Adolfo Di Nardo, Giovanni Battaglia, Giuseppe Tringale, Rosario De Vivo, Salvatore Compagna, Rita Tolva, Valerio S. D’Alessio, Ilenia Curci, Ruggiero Giovannetti, Simona D’Arrigo, Giuseppe Basile, Giusi Frigerio, Dalmazio Veraldi, Gian Franco Mezzetto, Luca Ippoliti, Arnaldo Oddi, Fabio M. Settembrini, Alberto M. |
| author_facet | Martelli, Eugenio Zamboni, Matilde Sotgiu, Giovanni Saderi, Laura Federici, Massimo Sangiorgi, Giuseppe M. Puci, Mariangela V. Martelli, Allegra R. Messina, Teresa Frigatti, Paolo Borrelli, Maria Pia Ruotolo, Carlo Ficarelli, Ilaria Rubino, Paolo Pezzo, Francesco Carbonari, Luciano Angelini, Andrea Galeazzi, Edoardo Di Pinto, Luca Calia Fiore, Franco M. Palmieri, Armando Ventoruzzo, Giorgio Mazzitelli, Giulia Ragni, Franco Bozzani, Antonio Forliti, Enzo Castagno, Claudio Volpe, Pietro Massara, Mafalda Moniaci, Diego Pagliasso, Elisa Peretti, Tania Ferrari, Mauro Troisi, Nicola Modugno, Piero Maiorano, Maurizio Bracale, Umberto M. Panagrosso, Marco Monaco, Mario Giordano, Giovanni Natalicchio, Giuseppe Biello, Antonella Celoria, Giovanni M. Amico, Alessio Di Bartolo, Mauro Martelli, Massimiliano Munaó, Roberta Razzano, Davide Colacchio, Giovanni Bussetti, Francesco Lanza, Gaetano Cardini, Antonio Di Benedetto, Bartolomeo De Laurentis, Mario Taurino, Maurizio Sirignano, Pasqualino Cappiello, Pierluigi Esposito, Andrea Trimarchi, Santi Romagnoli, Silvia Padricelli, Andrea Giudice, Giorgio Crinisio, Adolfo Di Nardo, Giovanni Battaglia, Giuseppe Tringale, Rosario De Vivo, Salvatore Compagna, Rita Tolva, Valerio S. D’Alessio, Ilenia Curci, Ruggiero Giovannetti, Simona D’Arrigo, Giuseppe Basile, Giusi Frigerio, Dalmazio Veraldi, Gian Franco Mezzetto, Luca Ippoliti, Arnaldo Oddi, Fabio M. Settembrini, Alberto M. |
| author_sort | Martelli, Eugenio |
| collection | PubMed |
| description | Background: Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI). Methods: Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients operated on for CLTI in 2019. Acute lower-limb ischemia and neuropathic-diabetic foot are not included. Follow-up: One year. Data on demographics/comorbidities, treatments/outcomes, and 30 day/1 year mortality were investigated. Results: Information on 2399 cases (69.8% men) from 36/143 (25.2%) centers. Median (IQR) age: 73 (66–80) and 79 (71–85) years for men/women, respectively (p < 0.0001). Women were more likely to be over 75 (63.2% vs. 40.1%, p = 0.0001). More men smokers (73.7% vs. 42.2%, p < 0.0001), are on hemodialysis (10.1% vs. 6.7%, p = 0.006), affected by diabetes (61.9% vs. 52.8%, p < 0.0001), dyslipidemia (69.3% vs. 61.3%, p < 0.0001), hypertension (91.8% vs. 88.5%, p = 0.011), coronaropathy (43.9% vs. 29.4%, p < 0.0001), bronchopneumopathy (37.1% vs. 25.6%, p < 0.0001), underwent more open/hybrid surgeries (37.9% vs. 28.8%, p < 0.0001), and minor amputations (22% vs. 13.7%, p < 0.0001). More women underwent endovascular revascularizations (61.6% vs. 55.2%, p = 0.004), major amputations (9.6% vs. 6.9%, p = 0.024), and obtained limb-salvage if with limited gangrene (50.8% vs. 44.9%, p = 0.017). Age > 75 (HR = 3.63, p = 0.003) is associated with 30 day mortality. Age > 75 (HR = 2.14, p < 0.0001), nephropathy (HR = 1.54, p < 0.0001), coronaropathy (HR = 1.26, p = 0.036), and infection/necrosis of the foot (dry, HR = 1.42, p = 0.040; wet, HR = 2.04, p < 0.0001) are associated with 1 year mortality. No sex-linked difference in mortality statistics. Conclusion: Women exhibit fewer comorbidities but are struck by CLTI when over 75, a factor associated with short- and mid-term mortality, explaining why mortality does not statistically differ between the sexes. |
| format | Online Article Text |
| id | pubmed-9959358 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99593582023-02-26 Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry Martelli, Eugenio Zamboni, Matilde Sotgiu, Giovanni Saderi, Laura Federici, Massimo Sangiorgi, Giuseppe M. Puci, Mariangela V. Martelli, Allegra R. Messina, Teresa Frigatti, Paolo Borrelli, Maria Pia Ruotolo, Carlo Ficarelli, Ilaria Rubino, Paolo Pezzo, Francesco Carbonari, Luciano Angelini, Andrea Galeazzi, Edoardo Di Pinto, Luca Calia Fiore, Franco M. Palmieri, Armando Ventoruzzo, Giorgio Mazzitelli, Giulia Ragni, Franco Bozzani, Antonio Forliti, Enzo Castagno, Claudio Volpe, Pietro Massara, Mafalda Moniaci, Diego Pagliasso, Elisa Peretti, Tania Ferrari, Mauro Troisi, Nicola Modugno, Piero Maiorano, Maurizio Bracale, Umberto M. Panagrosso, Marco Monaco, Mario Giordano, Giovanni Natalicchio, Giuseppe Biello, Antonella Celoria, Giovanni M. Amico, Alessio Di Bartolo, Mauro Martelli, Massimiliano Munaó, Roberta Razzano, Davide Colacchio, Giovanni Bussetti, Francesco Lanza, Gaetano Cardini, Antonio Di Benedetto, Bartolomeo De Laurentis, Mario Taurino, Maurizio Sirignano, Pasqualino Cappiello, Pierluigi Esposito, Andrea Trimarchi, Santi Romagnoli, Silvia Padricelli, Andrea Giudice, Giorgio Crinisio, Adolfo Di Nardo, Giovanni Battaglia, Giuseppe Tringale, Rosario De Vivo, Salvatore Compagna, Rita Tolva, Valerio S. D’Alessio, Ilenia Curci, Ruggiero Giovannetti, Simona D’Arrigo, Giuseppe Basile, Giusi Frigerio, Dalmazio Veraldi, Gian Franco Mezzetto, Luca Ippoliti, Arnaldo Oddi, Fabio M. Settembrini, Alberto M. J Pers Med Article Background: Identifying sex-related differences/variables associated with 30 day/1 year mortality in patients with chronic limb-threatening ischemia (CLTI). Methods: Multicenter/retrospective/observational study. A database was sent to all the Italian vascular surgeries to collect all the patients operated on for CLTI in 2019. Acute lower-limb ischemia and neuropathic-diabetic foot are not included. Follow-up: One year. Data on demographics/comorbidities, treatments/outcomes, and 30 day/1 year mortality were investigated. Results: Information on 2399 cases (69.8% men) from 36/143 (25.2%) centers. Median (IQR) age: 73 (66–80) and 79 (71–85) years for men/women, respectively (p < 0.0001). Women were more likely to be over 75 (63.2% vs. 40.1%, p = 0.0001). More men smokers (73.7% vs. 42.2%, p < 0.0001), are on hemodialysis (10.1% vs. 6.7%, p = 0.006), affected by diabetes (61.9% vs. 52.8%, p < 0.0001), dyslipidemia (69.3% vs. 61.3%, p < 0.0001), hypertension (91.8% vs. 88.5%, p = 0.011), coronaropathy (43.9% vs. 29.4%, p < 0.0001), bronchopneumopathy (37.1% vs. 25.6%, p < 0.0001), underwent more open/hybrid surgeries (37.9% vs. 28.8%, p < 0.0001), and minor amputations (22% vs. 13.7%, p < 0.0001). More women underwent endovascular revascularizations (61.6% vs. 55.2%, p = 0.004), major amputations (9.6% vs. 6.9%, p = 0.024), and obtained limb-salvage if with limited gangrene (50.8% vs. 44.9%, p = 0.017). Age > 75 (HR = 3.63, p = 0.003) is associated with 30 day mortality. Age > 75 (HR = 2.14, p < 0.0001), nephropathy (HR = 1.54, p < 0.0001), coronaropathy (HR = 1.26, p = 0.036), and infection/necrosis of the foot (dry, HR = 1.42, p = 0.040; wet, HR = 2.04, p < 0.0001) are associated with 1 year mortality. No sex-linked difference in mortality statistics. Conclusion: Women exhibit fewer comorbidities but are struck by CLTI when over 75, a factor associated with short- and mid-term mortality, explaining why mortality does not statistically differ between the sexes. MDPI 2023-02-11 /pmc/articles/PMC9959358/ /pubmed/36836550 http://dx.doi.org/10.3390/jpm13020316 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Martelli, Eugenio Zamboni, Matilde Sotgiu, Giovanni Saderi, Laura Federici, Massimo Sangiorgi, Giuseppe M. Puci, Mariangela V. Martelli, Allegra R. Messina, Teresa Frigatti, Paolo Borrelli, Maria Pia Ruotolo, Carlo Ficarelli, Ilaria Rubino, Paolo Pezzo, Francesco Carbonari, Luciano Angelini, Andrea Galeazzi, Edoardo Di Pinto, Luca Calia Fiore, Franco M. Palmieri, Armando Ventoruzzo, Giorgio Mazzitelli, Giulia Ragni, Franco Bozzani, Antonio Forliti, Enzo Castagno, Claudio Volpe, Pietro Massara, Mafalda Moniaci, Diego Pagliasso, Elisa Peretti, Tania Ferrari, Mauro Troisi, Nicola Modugno, Piero Maiorano, Maurizio Bracale, Umberto M. Panagrosso, Marco Monaco, Mario Giordano, Giovanni Natalicchio, Giuseppe Biello, Antonella Celoria, Giovanni M. Amico, Alessio Di Bartolo, Mauro Martelli, Massimiliano Munaó, Roberta Razzano, Davide Colacchio, Giovanni Bussetti, Francesco Lanza, Gaetano Cardini, Antonio Di Benedetto, Bartolomeo De Laurentis, Mario Taurino, Maurizio Sirignano, Pasqualino Cappiello, Pierluigi Esposito, Andrea Trimarchi, Santi Romagnoli, Silvia Padricelli, Andrea Giudice, Giorgio Crinisio, Adolfo Di Nardo, Giovanni Battaglia, Giuseppe Tringale, Rosario De Vivo, Salvatore Compagna, Rita Tolva, Valerio S. D’Alessio, Ilenia Curci, Ruggiero Giovannetti, Simona D’Arrigo, Giuseppe Basile, Giusi Frigerio, Dalmazio Veraldi, Gian Franco Mezzetto, Luca Ippoliti, Arnaldo Oddi, Fabio M. Settembrini, Alberto M. Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry |
| title | Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry |
| title_full | Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry |
| title_fullStr | Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry |
| title_full_unstemmed | Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry |
| title_short | Sex-Related Differences and Factors Associated with Peri-Procedural and 1 Year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry |
| title_sort | sex-related differences and factors associated with peri-procedural and 1 year mortality in chronic limb-threatening ischemia patients from the climate italian registry |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959358/ https://www.ncbi.nlm.nih.gov/pubmed/36836550 http://dx.doi.org/10.3390/jpm13020316 |
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