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Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy

Steroidogenic factor-1 (SF-1, also termed Ad4BP; NR5A1 in the official nomenclature) is a nuclear receptor transcription factor that plays a crucial role in the regulation of adrenal and gonadal development, function and maintenance. In addition to its classical role in regulating the expression of...

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Autores principales: Relav, Lauriane, Doghman-Bouguerra, Mabrouka, Ruggiero, Carmen, Muzzi, João C. D., Figueiredo, Bonald C., Lalli, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959402/
https://www.ncbi.nlm.nih.gov/pubmed/36835002
http://dx.doi.org/10.3390/ijms24043585
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author Relav, Lauriane
Doghman-Bouguerra, Mabrouka
Ruggiero, Carmen
Muzzi, João C. D.
Figueiredo, Bonald C.
Lalli, Enzo
author_facet Relav, Lauriane
Doghman-Bouguerra, Mabrouka
Ruggiero, Carmen
Muzzi, João C. D.
Figueiredo, Bonald C.
Lalli, Enzo
author_sort Relav, Lauriane
collection PubMed
description Steroidogenic factor-1 (SF-1, also termed Ad4BP; NR5A1 in the official nomenclature) is a nuclear receptor transcription factor that plays a crucial role in the regulation of adrenal and gonadal development, function and maintenance. In addition to its classical role in regulating the expression of P450 steroid hydroxylases and other steroidogenic genes, involvement in other key processes such as cell survival/proliferation and cytoskeleton dynamics have also been highlighted for SF-1. SF-1 has a restricted pattern of expression, being expressed along the hypothalamic-pituitary axis and in steroidogenic organs since the time of their establishment. Reduced SF-1 expression affects proper gonadal and adrenal organogenesis and function. On the other hand, SF-1 overexpression is found in adrenocortical carcinoma and represents a prognostic marker for patients’ survival. This review is focused on the current knowledge about SF-1 and the crucial importance of its dosage for adrenal gland development and function, from its involvement in adrenal cortex formation to tumorigenesis. Overall, data converge towards SF-1 being a key player in the complex network of transcriptional regulation within the adrenal gland in a dosage-dependent manner.
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spelling pubmed-99594022023-02-26 Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy Relav, Lauriane Doghman-Bouguerra, Mabrouka Ruggiero, Carmen Muzzi, João C. D. Figueiredo, Bonald C. Lalli, Enzo Int J Mol Sci Article Steroidogenic factor-1 (SF-1, also termed Ad4BP; NR5A1 in the official nomenclature) is a nuclear receptor transcription factor that plays a crucial role in the regulation of adrenal and gonadal development, function and maintenance. In addition to its classical role in regulating the expression of P450 steroid hydroxylases and other steroidogenic genes, involvement in other key processes such as cell survival/proliferation and cytoskeleton dynamics have also been highlighted for SF-1. SF-1 has a restricted pattern of expression, being expressed along the hypothalamic-pituitary axis and in steroidogenic organs since the time of their establishment. Reduced SF-1 expression affects proper gonadal and adrenal organogenesis and function. On the other hand, SF-1 overexpression is found in adrenocortical carcinoma and represents a prognostic marker for patients’ survival. This review is focused on the current knowledge about SF-1 and the crucial importance of its dosage for adrenal gland development and function, from its involvement in adrenal cortex formation to tumorigenesis. Overall, data converge towards SF-1 being a key player in the complex network of transcriptional regulation within the adrenal gland in a dosage-dependent manner. MDPI 2023-02-10 /pmc/articles/PMC9959402/ /pubmed/36835002 http://dx.doi.org/10.3390/ijms24043585 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Relav, Lauriane
Doghman-Bouguerra, Mabrouka
Ruggiero, Carmen
Muzzi, João C. D.
Figueiredo, Bonald C.
Lalli, Enzo
Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy
title Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy
title_full Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy
title_fullStr Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy
title_full_unstemmed Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy
title_short Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy
title_sort steroidogenic factor 1, a goldilocks transcription factor from adrenocortical organogenesis to malignancy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959402/
https://www.ncbi.nlm.nih.gov/pubmed/36835002
http://dx.doi.org/10.3390/ijms24043585
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