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The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis

Background: Somatostatin analogues (SSAs) are the cornerstone of treatment for carcinoid syndrome (CS)-related symptoms. The aim of this systematic review and meta-analysis is to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of long-acting SSAs in...

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Autores principales: Alexandraki, Krystallenia I., Angelousi, Anna, Chatzellis, Eleftherios, Chrisoulidou, Alexandra, Kalogeris, Nikolaos, Kanakis, Georgios, Savvidis, Christos, Vassiliadi, Dimitra, Spyroglou, Ariadni, Kostopoulos, Georgios, Markussis, Vyron, Toulis, Konstantinos, Tsagarakis, Stylianos, Kaltsas, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959441/
https://www.ncbi.nlm.nih.gov/pubmed/36836538
http://dx.doi.org/10.3390/jpm13020304
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author Alexandraki, Krystallenia I.
Angelousi, Anna
Chatzellis, Eleftherios
Chrisoulidou, Alexandra
Kalogeris, Nikolaos
Kanakis, Georgios
Savvidis, Christos
Vassiliadi, Dimitra
Spyroglou, Ariadni
Kostopoulos, Georgios
Markussis, Vyron
Toulis, Konstantinos
Tsagarakis, Stylianos
Kaltsas, Gregory A.
author_facet Alexandraki, Krystallenia I.
Angelousi, Anna
Chatzellis, Eleftherios
Chrisoulidou, Alexandra
Kalogeris, Nikolaos
Kanakis, Georgios
Savvidis, Christos
Vassiliadi, Dimitra
Spyroglou, Ariadni
Kostopoulos, Georgios
Markussis, Vyron
Toulis, Konstantinos
Tsagarakis, Stylianos
Kaltsas, Gregory A.
author_sort Alexandraki, Krystallenia I.
collection PubMed
description Background: Somatostatin analogues (SSAs) are the cornerstone of treatment for carcinoid syndrome (CS)-related symptoms. The aim of this systematic review and meta-analysis is to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of long-acting SSAs in patients with CS. Methods: A systematic electronic literature search was conducted in PubMed, Cochrane, and Scopus to identify eligible studies. Any clinical trials reporting data on the efficacy of SSAs to alleviate symptoms in adult patients were considered as potentially eligible. Results: A total of 17 studies reported extractable outcomes (PR/CR) for quantitative synthesis. The pooled percentage of patients with PR/CR for diarrhea was estimated to be 0.67 (95% confidence interval (CI): 0.52–0.79, I(2) = 83%). Subgroup analyses of specific drugs provided no evidence of a differential response. With regards to flushing, the pooled percentage of patients with PR/CR was estimated to be 0.68 (95% CI: 0.52–0.81, I(2) = 86%). Similarly, no evidence of a significant differential response in flushing control was documented. Conclusions: We estimate there is a 67–68% overall reduction in symptoms of CS associated with SSA treatment. However, significant heterogeneity was detected, possibly revealing differences in the disease course, in management and in outcome definition.
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spelling pubmed-99594412023-02-26 The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis Alexandraki, Krystallenia I. Angelousi, Anna Chatzellis, Eleftherios Chrisoulidou, Alexandra Kalogeris, Nikolaos Kanakis, Georgios Savvidis, Christos Vassiliadi, Dimitra Spyroglou, Ariadni Kostopoulos, Georgios Markussis, Vyron Toulis, Konstantinos Tsagarakis, Stylianos Kaltsas, Gregory A. J Pers Med Review Background: Somatostatin analogues (SSAs) are the cornerstone of treatment for carcinoid syndrome (CS)-related symptoms. The aim of this systematic review and meta-analysis is to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of long-acting SSAs in patients with CS. Methods: A systematic electronic literature search was conducted in PubMed, Cochrane, and Scopus to identify eligible studies. Any clinical trials reporting data on the efficacy of SSAs to alleviate symptoms in adult patients were considered as potentially eligible. Results: A total of 17 studies reported extractable outcomes (PR/CR) for quantitative synthesis. The pooled percentage of patients with PR/CR for diarrhea was estimated to be 0.67 (95% confidence interval (CI): 0.52–0.79, I(2) = 83%). Subgroup analyses of specific drugs provided no evidence of a differential response. With regards to flushing, the pooled percentage of patients with PR/CR was estimated to be 0.68 (95% CI: 0.52–0.81, I(2) = 86%). Similarly, no evidence of a significant differential response in flushing control was documented. Conclusions: We estimate there is a 67–68% overall reduction in symptoms of CS associated with SSA treatment. However, significant heterogeneity was detected, possibly revealing differences in the disease course, in management and in outcome definition. MDPI 2023-02-09 /pmc/articles/PMC9959441/ /pubmed/36836538 http://dx.doi.org/10.3390/jpm13020304 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alexandraki, Krystallenia I.
Angelousi, Anna
Chatzellis, Eleftherios
Chrisoulidou, Alexandra
Kalogeris, Nikolaos
Kanakis, Georgios
Savvidis, Christos
Vassiliadi, Dimitra
Spyroglou, Ariadni
Kostopoulos, Georgios
Markussis, Vyron
Toulis, Konstantinos
Tsagarakis, Stylianos
Kaltsas, Gregory A.
The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis
title The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis
title_full The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis
title_fullStr The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis
title_full_unstemmed The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis
title_short The Role of Somatostatin Analogues in the Control of Diarrhea and Flushing as Markers of Carcinoid Syndrome: A Systematic Review and Meta-Analysis
title_sort role of somatostatin analogues in the control of diarrhea and flushing as markers of carcinoid syndrome: a systematic review and meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959441/
https://www.ncbi.nlm.nih.gov/pubmed/36836538
http://dx.doi.org/10.3390/jpm13020304
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