SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2

Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2, which requires cleavage of its spike protein (S) at two sites: S1/S2 and S2′. This study inves...

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Detalles Bibliográficos
Autores principales: Essalmani, Rachid, Andréo, Ursula, Evagelidis, Alexandra, Le Dévéhat, Maïlys, Pereira Ramos, Oscar Henrique, Fruchart Gaillard, Carole, Susan-Resiga, Delia, Cohen, Éric A., Seidah, Nabil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959508/
https://www.ncbi.nlm.nih.gov/pubmed/36851576
http://dx.doi.org/10.3390/v15020360

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