Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand

Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity...

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Autores principales: Liang, Xiaoqin, Niu, Peng, Li, Jun, Guan, Xinlan, Zhang, Yanjun, Li, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959541/
https://www.ncbi.nlm.nih.gov/pubmed/36838650
http://dx.doi.org/10.3390/molecules28041658
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author Liang, Xiaoqin
Niu, Peng
Li, Jun
Guan, Xinlan
Zhang, Yanjun
Li, Jian
author_facet Liang, Xiaoqin
Niu, Peng
Li, Jun
Guan, Xinlan
Zhang, Yanjun
Li, Jian
author_sort Liang, Xiaoqin
collection PubMed
description Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC(50) value of 10.33 μM. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents.
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spelling pubmed-99595412023-02-26 Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand Liang, Xiaoqin Niu, Peng Li, Jun Guan, Xinlan Zhang, Yanjun Li, Jian Molecules Article Two new triterpenoid glucosides, Heritiera A (1) and Heritiera B (2), and six known triterpenoid analogs (3–8) were isolated from Heritiera littoralis Dryand. Their structures were identified by comprehensive spectroscopic analyses and comparisons with the literature. The anti-inflammatory activity of the isolates from H. littoralis was evaluated using a lipopolysaccharide (LPS) stimulated RAW 264.7 cells model. The result showed that four triterpenoids exhibited potent anti-inflammatory activity. Among these compounds, compound 2 substantially inhibits the release of nitric oxide (NO) with an IC(50) value of 10.33 μM. The triterpenoids from H. littoralis could be used as potential candidates for the development of new anti-inflammatory agents. MDPI 2023-02-09 /pmc/articles/PMC9959541/ /pubmed/36838650 http://dx.doi.org/10.3390/molecules28041658 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liang, Xiaoqin
Niu, Peng
Li, Jun
Guan, Xinlan
Zhang, Yanjun
Li, Jian
Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand
title Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand
title_full Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand
title_fullStr Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand
title_full_unstemmed Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand
title_short Discovery of Anti-Inflammatory Triterpenoid Glucosides from the Heritiera littoralis Dryand
title_sort discovery of anti-inflammatory triterpenoid glucosides from the heritiera littoralis dryand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959541/
https://www.ncbi.nlm.nih.gov/pubmed/36838650
http://dx.doi.org/10.3390/molecules28041658
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