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Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser
For normal operations, microfluidic devices typically require an external source of pressure to deliver fluid flow through the microchannel. This requirement limits their use for benchtop research activities in a controlled static environment. To exploit the full potential of the miniaturization and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959566/ https://www.ncbi.nlm.nih.gov/pubmed/36838024 http://dx.doi.org/10.3390/mi14020324 |
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author | Thaweeskulchai, Thana Schulte, Albert |
author_facet | Thaweeskulchai, Thana Schulte, Albert |
author_sort | Thaweeskulchai, Thana |
collection | PubMed |
description | For normal operations, microfluidic devices typically require an external source of pressure to deliver fluid flow through the microchannel. This requirement limits their use for benchtop research activities in a controlled static environment. To exploit the full potential of the miniaturization and portability of microfluidic platforms, passively driven capillary microfluidic devices have been developed to completely remove the need for an external pressure source. Capillary microfluidics can be designed to perform complex tasks by designing individual components of the device. These components, such as the stop valve and trigger valve, operate through changes in microchannel dimensions and aspect ratios. A direct, maskless fabrication protocol that allows the precise fabrication of microchannels and other microfluidic components is introduced here. A diode laser and polyimide tape on a PMMA substrate are the only components needed to start fabrication. By varying the laser power used and the number of laser repetitions, various depths and widths of the microchannel can be quickly created to meet specific needs. As an example of a functional unit, a trigger valve was fabricated and tested, as proof of the validity of the fabrication protocol. |
format | Online Article Text |
id | pubmed-9959566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99595662023-02-26 Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser Thaweeskulchai, Thana Schulte, Albert Micromachines (Basel) Article For normal operations, microfluidic devices typically require an external source of pressure to deliver fluid flow through the microchannel. This requirement limits their use for benchtop research activities in a controlled static environment. To exploit the full potential of the miniaturization and portability of microfluidic platforms, passively driven capillary microfluidic devices have been developed to completely remove the need for an external pressure source. Capillary microfluidics can be designed to perform complex tasks by designing individual components of the device. These components, such as the stop valve and trigger valve, operate through changes in microchannel dimensions and aspect ratios. A direct, maskless fabrication protocol that allows the precise fabrication of microchannels and other microfluidic components is introduced here. A diode laser and polyimide tape on a PMMA substrate are the only components needed to start fabrication. By varying the laser power used and the number of laser repetitions, various depths and widths of the microchannel can be quickly created to meet specific needs. As an example of a functional unit, a trigger valve was fabricated and tested, as proof of the validity of the fabrication protocol. MDPI 2023-01-27 /pmc/articles/PMC9959566/ /pubmed/36838024 http://dx.doi.org/10.3390/mi14020324 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Thaweeskulchai, Thana Schulte, Albert Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser |
title | Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser |
title_full | Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser |
title_fullStr | Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser |
title_full_unstemmed | Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser |
title_short | Basic Guide to Multilayer Microfluidic Fabrication with Polyimide Tape and Diode Laser |
title_sort | basic guide to multilayer microfluidic fabrication with polyimide tape and diode laser |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959566/ https://www.ncbi.nlm.nih.gov/pubmed/36838024 http://dx.doi.org/10.3390/mi14020324 |
work_keys_str_mv | AT thaweeskulchaithana basicguidetomultilayermicrofluidicfabricationwithpolyimidetapeanddiodelaser AT schultealbert basicguidetomultilayermicrofluidicfabricationwithpolyimidetapeanddiodelaser |