Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation

A polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the sialyl α(2→3) lactose derivative to afford the de...

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Autores principales: Adachi, Ryota, Matsushita, Takahiko, Koyama, Tetsuo, Hatano, Ken, Matsuoka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959589/
https://www.ncbi.nlm.nih.gov/pubmed/36850281
http://dx.doi.org/10.3390/polym15040998
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author Adachi, Ryota
Matsushita, Takahiko
Koyama, Tetsuo
Hatano, Ken
Matsuoka, Koji
author_facet Adachi, Ryota
Matsushita, Takahiko
Koyama, Tetsuo
Hatano, Ken
Matsuoka, Koji
author_sort Adachi, Ryota
collection PubMed
description A polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the sialyl α(2→3) lactose derivative to afford the desired glycomonomer, which was further polymerized with or without acrylamide to give water-soluble glycopolymers. The glycopolymers had higher affinities than those of glycopolymers having sialyl lactose moieties with shorter aglycon moieties.
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spelling pubmed-99595892023-02-26 Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation Adachi, Ryota Matsushita, Takahiko Koyama, Tetsuo Hatano, Ken Matsuoka, Koji Polymers (Basel) Article A polymerizable alcohol having 9 PEG repeats was prepared in order to mimic an oligosaccharide moiety. Sialyl α(2→3) lactose, which is known as a sugar moiety of GM3 ganglioside, was also prepared, and the polymerizable alcohol was condensed with the sialyl α(2→3) lactose derivative to afford the desired glycomonomer, which was further polymerized with or without acrylamide to give water-soluble glycopolymers. The glycopolymers had higher affinities than those of glycopolymers having sialyl lactose moieties with shorter aglycon moieties. MDPI 2023-02-17 /pmc/articles/PMC9959589/ /pubmed/36850281 http://dx.doi.org/10.3390/polym15040998 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Adachi, Ryota
Matsushita, Takahiko
Koyama, Tetsuo
Hatano, Ken
Matsuoka, Koji
Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation
title Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation
title_full Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation
title_fullStr Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation
title_full_unstemmed Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation
title_short Use of a Longer Aglycon Moiety Bearing Sialyl α(2→3) Lactoside on the Glycopolymer for Lectin Evaluation
title_sort use of a longer aglycon moiety bearing sialyl α(2→3) lactoside on the glycopolymer for lectin evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959589/
https://www.ncbi.nlm.nih.gov/pubmed/36850281
http://dx.doi.org/10.3390/polym15040998
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