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Burns: Classification, Pathophysiology, and Treatment: A Review
Burns and their treatment are a significant medical problem. The loss of the physical barrier function of the skin opens the door to microbial invasion and can lead to infection. The repair process of the damage caused by the burn is impaired due to the enhanced loss of fluids and minerals through t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959609/ https://www.ncbi.nlm.nih.gov/pubmed/36835171 http://dx.doi.org/10.3390/ijms24043749 |
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author | Żwierełło, Wojciech Piorun, Krzysztof Skórka-Majewicz, Marta Maruszewska, Agnieszka Antoniewski, Jacek Gutowska, Izabela |
author_facet | Żwierełło, Wojciech Piorun, Krzysztof Skórka-Majewicz, Marta Maruszewska, Agnieszka Antoniewski, Jacek Gutowska, Izabela |
author_sort | Żwierełło, Wojciech |
collection | PubMed |
description | Burns and their treatment are a significant medical problem. The loss of the physical barrier function of the skin opens the door to microbial invasion and can lead to infection. The repair process of the damage caused by the burn is impaired due to the enhanced loss of fluids and minerals through the burn wound, the onset of hypermetabolism with the concomitant disruption of nutrient supply, and derangements in the endocrine system. In addition, the initiated inflammatory and free radical processes drive the progression of oxidative stress, the inhibition of which largely depends on an adequate supply of antioxidants and minerals. Clinical experience and research provide more and more data to make the treatment of patients with thermal injury increasingly effective. The publication discusses disorders occurring in patients after thermal injury and the methods used at various stages of treatment. |
format | Online Article Text |
id | pubmed-9959609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99596092023-02-26 Burns: Classification, Pathophysiology, and Treatment: A Review Żwierełło, Wojciech Piorun, Krzysztof Skórka-Majewicz, Marta Maruszewska, Agnieszka Antoniewski, Jacek Gutowska, Izabela Int J Mol Sci Review Burns and their treatment are a significant medical problem. The loss of the physical barrier function of the skin opens the door to microbial invasion and can lead to infection. The repair process of the damage caused by the burn is impaired due to the enhanced loss of fluids and minerals through the burn wound, the onset of hypermetabolism with the concomitant disruption of nutrient supply, and derangements in the endocrine system. In addition, the initiated inflammatory and free radical processes drive the progression of oxidative stress, the inhibition of which largely depends on an adequate supply of antioxidants and minerals. Clinical experience and research provide more and more data to make the treatment of patients with thermal injury increasingly effective. The publication discusses disorders occurring in patients after thermal injury and the methods used at various stages of treatment. MDPI 2023-02-13 /pmc/articles/PMC9959609/ /pubmed/36835171 http://dx.doi.org/10.3390/ijms24043749 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Żwierełło, Wojciech Piorun, Krzysztof Skórka-Majewicz, Marta Maruszewska, Agnieszka Antoniewski, Jacek Gutowska, Izabela Burns: Classification, Pathophysiology, and Treatment: A Review |
title | Burns: Classification, Pathophysiology, and Treatment: A Review |
title_full | Burns: Classification, Pathophysiology, and Treatment: A Review |
title_fullStr | Burns: Classification, Pathophysiology, and Treatment: A Review |
title_full_unstemmed | Burns: Classification, Pathophysiology, and Treatment: A Review |
title_short | Burns: Classification, Pathophysiology, and Treatment: A Review |
title_sort | burns: classification, pathophysiology, and treatment: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959609/ https://www.ncbi.nlm.nih.gov/pubmed/36835171 http://dx.doi.org/10.3390/ijms24043749 |
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