Cargando…

Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications

Development of new biomaterials based on polysulfones tailored to act in various biomedical fields represents a promising strategy which provides an opportunity for enhancing the diagnosis, prevention, and treatment of specific illnesses. To meet these requirements, structural modification of the po...

Descripción completa

Detalles Bibliográficos
Autores principales: Dobos, Adina Maria, Popa, Adriana, Rimbu, Cristina Mihaela, Filimon, Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959649/
https://www.ncbi.nlm.nih.gov/pubmed/36850167
http://dx.doi.org/10.3390/polym15040877
Descripción
Sumario:Development of new biomaterials based on polysulfones tailored to act in various biomedical fields represents a promising strategy which provides an opportunity for enhancing the diagnosis, prevention, and treatment of specific illnesses. To meet these requirements, structural modification of the polysulfones is essential. In this context, for design of new materials with long-term stability, enhanced workability, compatibility with biological materials and good antimicrobial activity, the functionalization of chloromethylated polysulfones with triethylphosphonium pendant groups (PSFEtP+) was adopted. The surface chemistry analysis (Fourier transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDX)), rheological properties, morphological aspects (Scanning electron microscopy (SEM), polarized light microscopy (POM)), and antimicrobial activity of the synthetized polysulfone were investigated to establish the relationship between its structure and properties, as an important indicator for targeted applications. Based on the obtained features, evaluated by the relationship between the rheological properties and microstructural aspects, and also the response at the biomaterial-bacteria interface, these qualities have been confirmed in their performance, in terms of thermal stability, antimicrobial activity, and also an increase in lifetime. Consequently, derived results constitute the preliminary basis for future tests concerning their functionality as gel matrices in biomedical devices.