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Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications
Development of new biomaterials based on polysulfones tailored to act in various biomedical fields represents a promising strategy which provides an opportunity for enhancing the diagnosis, prevention, and treatment of specific illnesses. To meet these requirements, structural modification of the po...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959649/ https://www.ncbi.nlm.nih.gov/pubmed/36850167 http://dx.doi.org/10.3390/polym15040877 |
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author | Dobos, Adina Maria Popa, Adriana Rimbu, Cristina Mihaela Filimon, Anca |
author_facet | Dobos, Adina Maria Popa, Adriana Rimbu, Cristina Mihaela Filimon, Anca |
author_sort | Dobos, Adina Maria |
collection | PubMed |
description | Development of new biomaterials based on polysulfones tailored to act in various biomedical fields represents a promising strategy which provides an opportunity for enhancing the diagnosis, prevention, and treatment of specific illnesses. To meet these requirements, structural modification of the polysulfones is essential. In this context, for design of new materials with long-term stability, enhanced workability, compatibility with biological materials and good antimicrobial activity, the functionalization of chloromethylated polysulfones with triethylphosphonium pendant groups (PSFEtP+) was adopted. The surface chemistry analysis (Fourier transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDX)), rheological properties, morphological aspects (Scanning electron microscopy (SEM), polarized light microscopy (POM)), and antimicrobial activity of the synthetized polysulfone were investigated to establish the relationship between its structure and properties, as an important indicator for targeted applications. Based on the obtained features, evaluated by the relationship between the rheological properties and microstructural aspects, and also the response at the biomaterial-bacteria interface, these qualities have been confirmed in their performance, in terms of thermal stability, antimicrobial activity, and also an increase in lifetime. Consequently, derived results constitute the preliminary basis for future tests concerning their functionality as gel matrices in biomedical devices. |
format | Online Article Text |
id | pubmed-9959649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99596492023-02-26 Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications Dobos, Adina Maria Popa, Adriana Rimbu, Cristina Mihaela Filimon, Anca Polymers (Basel) Article Development of new biomaterials based on polysulfones tailored to act in various biomedical fields represents a promising strategy which provides an opportunity for enhancing the diagnosis, prevention, and treatment of specific illnesses. To meet these requirements, structural modification of the polysulfones is essential. In this context, for design of new materials with long-term stability, enhanced workability, compatibility with biological materials and good antimicrobial activity, the functionalization of chloromethylated polysulfones with triethylphosphonium pendant groups (PSFEtP+) was adopted. The surface chemistry analysis (Fourier transform infrared spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDX)), rheological properties, morphological aspects (Scanning electron microscopy (SEM), polarized light microscopy (POM)), and antimicrobial activity of the synthetized polysulfone were investigated to establish the relationship between its structure and properties, as an important indicator for targeted applications. Based on the obtained features, evaluated by the relationship between the rheological properties and microstructural aspects, and also the response at the biomaterial-bacteria interface, these qualities have been confirmed in their performance, in terms of thermal stability, antimicrobial activity, and also an increase in lifetime. Consequently, derived results constitute the preliminary basis for future tests concerning their functionality as gel matrices in biomedical devices. MDPI 2023-02-10 /pmc/articles/PMC9959649/ /pubmed/36850167 http://dx.doi.org/10.3390/polym15040877 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Dobos, Adina Maria Popa, Adriana Rimbu, Cristina Mihaela Filimon, Anca Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications |
title | Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications |
title_full | Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications |
title_fullStr | Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications |
title_full_unstemmed | Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications |
title_short | Structure-Bioactivity Relationship of the Functionalized Polysulfone with Triethylphosphonium Pendant Groups: Perspective for Biomedical Applications |
title_sort | structure-bioactivity relationship of the functionalized polysulfone with triethylphosphonium pendant groups: perspective for biomedical applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959649/ https://www.ncbi.nlm.nih.gov/pubmed/36850167 http://dx.doi.org/10.3390/polym15040877 |
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