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Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients

(1) Background: Early thymectomy is suggested in all clinically indicated myasthenia gravis (MG) patients. However, short-term clinical response after thymectomy in MG patients has been limitedly described in the literature. This study aimed to compare the 5-year post-thymectomy outcomes between thy...

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Autores principales: Wiboonpong, Phattamon, Setthawatcharawanich, Suwanna, Korathanakhun, Pat, Amornpojnimman, Thanyalak, Pruphetkaew, Nannapat, Chongphattararot, Pensri, Sathirapanya, Chutarat, Sathirapanya, Pornchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959777/
https://www.ncbi.nlm.nih.gov/pubmed/36833734
http://dx.doi.org/10.3390/ijerph20043039
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author Wiboonpong, Phattamon
Setthawatcharawanich, Suwanna
Korathanakhun, Pat
Amornpojnimman, Thanyalak
Pruphetkaew, Nannapat
Chongphattararot, Pensri
Sathirapanya, Chutarat
Sathirapanya, Pornchai
author_facet Wiboonpong, Phattamon
Setthawatcharawanich, Suwanna
Korathanakhun, Pat
Amornpojnimman, Thanyalak
Pruphetkaew, Nannapat
Chongphattararot, Pensri
Sathirapanya, Chutarat
Sathirapanya, Pornchai
author_sort Wiboonpong, Phattamon
collection PubMed
description (1) Background: Early thymectomy is suggested in all clinically indicated myasthenia gravis (MG) patients. However, short-term clinical response after thymectomy in MG patients has been limitedly described in the literature. This study aimed to compare the 5-year post-thymectomy outcomes between thymoma (Th) and non-thymoma (non-Th) MG patients. (2) Methods: MG patients aged ≥18 years who underwent transsternal thymectomy and had tissue histopathology reports in Songklanagarind Hospital between 2002 and 2020 were enrolled in a retrospective review. The differences in the baseline demographics and clinical characteristics between ThMG and non-Th MG patients were studied. We compared the time-weighted averages (TWAs) of daily required dosages of pyridostigmine, prednisolone or azathioprine to efficiently maintain daily living activities and earnings between the MG patient groups during 5 consecutive years following thymectomy. Post-thymectomy clinical status, exacerbations or crises were followed. Descriptive statistics were used for analysis with statistical significance set at p < 0.05. (3) Results: ThMG patients had significantly older ages of onset and shorter times from the MG diagnosis to thymectomy. Male gender was the only significant factor associated with ThMG. TWAs of the daily MG treatment drug dosages required showed no differences between the groups. Additionally, the rates of exacerbations and crises were not different, but decremental trends were shown in both groups after the thymectomies. (4) Conclusions: The daily dosage requirements of MG treatment drugs were not different. There was a trend of decreasing adverse event rates despite no statistically significant differences during the first 5 years after thymectomy in ThMG and non-ThMG patients.
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spelling pubmed-99597772023-02-26 Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients Wiboonpong, Phattamon Setthawatcharawanich, Suwanna Korathanakhun, Pat Amornpojnimman, Thanyalak Pruphetkaew, Nannapat Chongphattararot, Pensri Sathirapanya, Chutarat Sathirapanya, Pornchai Int J Environ Res Public Health Article (1) Background: Early thymectomy is suggested in all clinically indicated myasthenia gravis (MG) patients. However, short-term clinical response after thymectomy in MG patients has been limitedly described in the literature. This study aimed to compare the 5-year post-thymectomy outcomes between thymoma (Th) and non-thymoma (non-Th) MG patients. (2) Methods: MG patients aged ≥18 years who underwent transsternal thymectomy and had tissue histopathology reports in Songklanagarind Hospital between 2002 and 2020 were enrolled in a retrospective review. The differences in the baseline demographics and clinical characteristics between ThMG and non-Th MG patients were studied. We compared the time-weighted averages (TWAs) of daily required dosages of pyridostigmine, prednisolone or azathioprine to efficiently maintain daily living activities and earnings between the MG patient groups during 5 consecutive years following thymectomy. Post-thymectomy clinical status, exacerbations or crises were followed. Descriptive statistics were used for analysis with statistical significance set at p < 0.05. (3) Results: ThMG patients had significantly older ages of onset and shorter times from the MG diagnosis to thymectomy. Male gender was the only significant factor associated with ThMG. TWAs of the daily MG treatment drug dosages required showed no differences between the groups. Additionally, the rates of exacerbations and crises were not different, but decremental trends were shown in both groups after the thymectomies. (4) Conclusions: The daily dosage requirements of MG treatment drugs were not different. There was a trend of decreasing adverse event rates despite no statistically significant differences during the first 5 years after thymectomy in ThMG and non-ThMG patients. MDPI 2023-02-09 /pmc/articles/PMC9959777/ /pubmed/36833734 http://dx.doi.org/10.3390/ijerph20043039 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wiboonpong, Phattamon
Setthawatcharawanich, Suwanna
Korathanakhun, Pat
Amornpojnimman, Thanyalak
Pruphetkaew, Nannapat
Chongphattararot, Pensri
Sathirapanya, Chutarat
Sathirapanya, Pornchai
Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients
title Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients
title_full Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients
title_fullStr Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients
title_full_unstemmed Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients
title_short Comparison of Short-Term Post-Thymectomy Outcomes by Time-Weighted Dosages of Drug Requirements between Thymoma and Non-Thymoma Myasthenia Gravis Patients
title_sort comparison of short-term post-thymectomy outcomes by time-weighted dosages of drug requirements between thymoma and non-thymoma myasthenia gravis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959777/
https://www.ncbi.nlm.nih.gov/pubmed/36833734
http://dx.doi.org/10.3390/ijerph20043039
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