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Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease

We aimed to identify cardiopulmonary long-term effects after severe COVID-19 disease as well as predictors of Long-COVID in a prospective registry. A total of 150 consecutive, hospitalized patients (February 2020 and April 2021) were included six months post hospital discharge for a clinical follow-...

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Autores principales: Niebauer, Julia Hanne, Binder-Rodriguez, Christina, Iscel, Ahmet, Schedl, Sarah, Capelle, Christophe, Kahr, Michael, Cadjo, Simona, Schamilow, Simon, Badr-Eslam, Roza, Lichtenauer, Michael, Toma, Aurel, Zoufaly, Alexander, Valenta, Rosmarie, Hoffmann, Sabine, Charwat-Resl, Silvia, Krestan, Christian, Hitzl, Wolfgang, Wenisch, Christoph, Bonderman, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959779/
https://www.ncbi.nlm.nih.gov/pubmed/36836071
http://dx.doi.org/10.3390/jcm12041536
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author Niebauer, Julia Hanne
Binder-Rodriguez, Christina
Iscel, Ahmet
Schedl, Sarah
Capelle, Christophe
Kahr, Michael
Cadjo, Simona
Schamilow, Simon
Badr-Eslam, Roza
Lichtenauer, Michael
Toma, Aurel
Zoufaly, Alexander
Valenta, Rosmarie
Hoffmann, Sabine
Charwat-Resl, Silvia
Krestan, Christian
Hitzl, Wolfgang
Wenisch, Christoph
Bonderman, Diana
author_facet Niebauer, Julia Hanne
Binder-Rodriguez, Christina
Iscel, Ahmet
Schedl, Sarah
Capelle, Christophe
Kahr, Michael
Cadjo, Simona
Schamilow, Simon
Badr-Eslam, Roza
Lichtenauer, Michael
Toma, Aurel
Zoufaly, Alexander
Valenta, Rosmarie
Hoffmann, Sabine
Charwat-Resl, Silvia
Krestan, Christian
Hitzl, Wolfgang
Wenisch, Christoph
Bonderman, Diana
author_sort Niebauer, Julia Hanne
collection PubMed
description We aimed to identify cardiopulmonary long-term effects after severe COVID-19 disease as well as predictors of Long-COVID in a prospective registry. A total of 150 consecutive, hospitalized patients (February 2020 and April 2021) were included six months post hospital discharge for a clinical follow-up. Among them, 49% experienced fatigue, 38% exertional dyspnea and 75% fulfilled criteria for Long-COVID. Echocardiography detected reduced global longitudinal strain (GLS) in 11% and diastolic dysfunction in 4%. Magnetic resonance imaging revealed traces of pericardial effusion in 18% and signs of former pericarditis or myocarditis in 4%. Pulmonary function was impaired in 11%. Chest computed tomography identified post-infectious residues in 22%. Whereas fatigue did not correlate with cardiopulmonary abnormalities, exertional dyspnea was associated with impaired pulmonary function (OR 3.6 [95% CI: 1.2–11], p = 0.026), reduced GLS (OR 5.2 [95% CI: 1.6–16.7], p = 0.003) and/or left ventricular diastolic dysfunction (OR 4.2 [95% CI: 1.03–17], p = 0.04). Predictors of Long-COVID included length of in-hospital stay (OR: 1.15 [95% CI: 1.05–1.26], p = 0.004), admission to intensive care unit (OR cannot be computed, p = 0.001) and higher NT-proBNP (OR: 1.5 [95% CI: 1.05–2.14], p = 0.026). Even 6 months after discharge, a majority fulfilled criteria for Long-COVID. While no associations between fatigue and cardiopulmonary abnormalities were found, exertional dyspnea correlated with impaired pulmonary function, reduced GLS and/or diastolic dysfunction.
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spelling pubmed-99597792023-02-26 Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease Niebauer, Julia Hanne Binder-Rodriguez, Christina Iscel, Ahmet Schedl, Sarah Capelle, Christophe Kahr, Michael Cadjo, Simona Schamilow, Simon Badr-Eslam, Roza Lichtenauer, Michael Toma, Aurel Zoufaly, Alexander Valenta, Rosmarie Hoffmann, Sabine Charwat-Resl, Silvia Krestan, Christian Hitzl, Wolfgang Wenisch, Christoph Bonderman, Diana J Clin Med Article We aimed to identify cardiopulmonary long-term effects after severe COVID-19 disease as well as predictors of Long-COVID in a prospective registry. A total of 150 consecutive, hospitalized patients (February 2020 and April 2021) were included six months post hospital discharge for a clinical follow-up. Among them, 49% experienced fatigue, 38% exertional dyspnea and 75% fulfilled criteria for Long-COVID. Echocardiography detected reduced global longitudinal strain (GLS) in 11% and diastolic dysfunction in 4%. Magnetic resonance imaging revealed traces of pericardial effusion in 18% and signs of former pericarditis or myocarditis in 4%. Pulmonary function was impaired in 11%. Chest computed tomography identified post-infectious residues in 22%. Whereas fatigue did not correlate with cardiopulmonary abnormalities, exertional dyspnea was associated with impaired pulmonary function (OR 3.6 [95% CI: 1.2–11], p = 0.026), reduced GLS (OR 5.2 [95% CI: 1.6–16.7], p = 0.003) and/or left ventricular diastolic dysfunction (OR 4.2 [95% CI: 1.03–17], p = 0.04). Predictors of Long-COVID included length of in-hospital stay (OR: 1.15 [95% CI: 1.05–1.26], p = 0.004), admission to intensive care unit (OR cannot be computed, p = 0.001) and higher NT-proBNP (OR: 1.5 [95% CI: 1.05–2.14], p = 0.026). Even 6 months after discharge, a majority fulfilled criteria for Long-COVID. While no associations between fatigue and cardiopulmonary abnormalities were found, exertional dyspnea correlated with impaired pulmonary function, reduced GLS and/or diastolic dysfunction. MDPI 2023-02-15 /pmc/articles/PMC9959779/ /pubmed/36836071 http://dx.doi.org/10.3390/jcm12041536 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Niebauer, Julia Hanne
Binder-Rodriguez, Christina
Iscel, Ahmet
Schedl, Sarah
Capelle, Christophe
Kahr, Michael
Cadjo, Simona
Schamilow, Simon
Badr-Eslam, Roza
Lichtenauer, Michael
Toma, Aurel
Zoufaly, Alexander
Valenta, Rosmarie
Hoffmann, Sabine
Charwat-Resl, Silvia
Krestan, Christian
Hitzl, Wolfgang
Wenisch, Christoph
Bonderman, Diana
Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease
title Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease
title_full Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease
title_fullStr Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease
title_full_unstemmed Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease
title_short Cardiopulmonary Long-Term Sequelae in Patients after Severe COVID-19 Disease
title_sort cardiopulmonary long-term sequelae in patients after severe covid-19 disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959779/
https://www.ncbi.nlm.nih.gov/pubmed/36836071
http://dx.doi.org/10.3390/jcm12041536
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