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Flow-Based Fmoc-SPPS Preparation and SAR Study of Cathelicidin-PY Reveals Selective Antimicrobial Activity

Antimicrobial peptides (AMPs) hold promise as novel therapeutics in the fight against multi-drug-resistant pathogens. Cathelicidin-PY (NH(2)-RKCNFLCKLKEKLRTVITSHIDKVLRPQG-COOH) is a 29-residue disulfide-cyclised antimicrobial peptide secreted as an innate host defence mechanism by the frog Paa yunna...

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Detalles Bibliográficos
Autores principales:	Dissanayake, Shama, He, Junming, Yang, Sung H., Brimble, Margaret A., Harris, Paul W. R., Cameron, Alan J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959817/ https://www.ncbi.nlm.nih.gov/pubmed/36838983 http://dx.doi.org/10.3390/molecules28041993

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