Classification of HEp-2 Staining Pattern Images Using Adapted Multilayer Perceptron Neural Network-Based Intra-Class Variation of Cell Shape

There exists a growing interest from the clinical practice research communities in the development of methods to automate HEp-2 stained cells classification procedure from histopathological images. Challenges faced by these methods include variations in cell densities and cell patterns, overfitting of features, large-scale data volume and stained cells. In this paper, a multi-class multilayer perceptron technique is adapted by adding a new hidden layer to calculate the variation in the mean, scale, kurtosis and skewness of higher order spectra features of the cell shape information. The adapted technique is then jointly trained and the probability of classification calculated using a Softmax activation function. This method is proposed to address overfitting, stained and large-scale data volume problems, and classify HEp-2 staining cells into six classes. An extensive experimental analysis is studied to verify the results of the proposed method. The technique has been trained and tested on the dataset from ICPR-2014 and ICPR-2016 competitions using the Task-1. The experimental results have shown that the proposed model achieved higher accuracy of 90.3% (with data augmentation) than of 87.5% (with no data augmentation). In addition, the proposed framework is compared with existing methods, as well as, the results of methods using in ICPR2014 and ICPR2016 competitions.The results demonstrate that our proposed method effectively outperforms recent methods.