Insights into organoid-based modeling of COVID-19 pathology

Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technolog...

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Autores principales: Boroojerdi, Mohadese Hashem, Al Jabry, Tariq, Mirarefin, Seyed Mohamad Javad, Albalushi, Halima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959938/
https://www.ncbi.nlm.nih.gov/pubmed/36841795
http://dx.doi.org/10.1186/s12985-023-01996-2
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author Boroojerdi, Mohadese Hashem
Al Jabry, Tariq
Mirarefin, Seyed Mohamad Javad
Albalushi, Halima
author_facet Boroojerdi, Mohadese Hashem
Al Jabry, Tariq
Mirarefin, Seyed Mohamad Javad
Albalushi, Halima
author_sort Boroojerdi, Mohadese Hashem
collection PubMed
description Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies.
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spelling pubmed-99599382023-02-26 Insights into organoid-based modeling of COVID-19 pathology Boroojerdi, Mohadese Hashem Al Jabry, Tariq Mirarefin, Seyed Mohamad Javad Albalushi, Halima Virol J Review Since December 2019, various types of strategies have been applied due to the emergent need to investigate the biology and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to discover a functional treatment. Different disease modeling systems, such as mini-organ technology, have been used to improve our understanding of SARS-CoV-2 physiology and pathology. During the past 2 years, regenerative medicine research has shown the supportive role of organoid modeling in controlling coronavirus disease 2019 (COVID-19) through optimal drug and therapeutic approach improvement. Here, we overview some efforts that have been made to study SARS-CoV-2 by mimicking COVID-19 using stem cells. In addition, we summarize a perspective of drug development in COVID-19 treatment via organoid-based studies. BioMed Central 2023-02-25 /pmc/articles/PMC9959938/ /pubmed/36841795 http://dx.doi.org/10.1186/s12985-023-01996-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Boroojerdi, Mohadese Hashem
Al Jabry, Tariq
Mirarefin, Seyed Mohamad Javad
Albalushi, Halima
Insights into organoid-based modeling of COVID-19 pathology
title Insights into organoid-based modeling of COVID-19 pathology
title_full Insights into organoid-based modeling of COVID-19 pathology
title_fullStr Insights into organoid-based modeling of COVID-19 pathology
title_full_unstemmed Insights into organoid-based modeling of COVID-19 pathology
title_short Insights into organoid-based modeling of COVID-19 pathology
title_sort insights into organoid-based modeling of covid-19 pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959938/
https://www.ncbi.nlm.nih.gov/pubmed/36841795
http://dx.doi.org/10.1186/s12985-023-01996-2
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