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Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases

The pancreas represents an important organ that has not been comprehensively studied in many fields. To fill this gap, many models have been generated, and traditional models have shown good performance in addressing pancreatic-related diseases, but are increasingly struggling to keep up with the ne...

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Detalles Bibliográficos
Autores principales: Liu, Yuxiang, Li, Nianshuang, Zhu, Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959977/
https://www.ncbi.nlm.nih.gov/pubmed/36835437
http://dx.doi.org/10.3390/ijms24044027
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author Liu, Yuxiang
Li, Nianshuang
Zhu, Yin
author_facet Liu, Yuxiang
Li, Nianshuang
Zhu, Yin
author_sort Liu, Yuxiang
collection PubMed
description The pancreas represents an important organ that has not been comprehensively studied in many fields. To fill this gap, many models have been generated, and traditional models have shown good performance in addressing pancreatic-related diseases, but are increasingly struggling to keep up with the need for further research due to ethical issues, genetic heterogeneity and difficult clinical translation. The new era calls for new and more reliable research models. Therefore, organoids have been proposed as a novel model for the evaluation of pancreatic-related diseases such as pancreatic malignancy, diabetes, and pancreatic cystic fibrosis. Compared with common traditional models, including 2D cell culture and gene editing mice, organoids derived from living humans or mice cause minimal harm to the donor, raise fewer ethical concerns, and reasonably address the claims of heterogeneity, which allows for the further development of pathogenesis studies and clinical trial analysis. In this review, we analyse studies on the use of pancreatic organoids in research on pancreatic-related diseases, discuss the advantages and disadvantages, and hypothesize future trends.
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spelling pubmed-99599772023-02-26 Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases Liu, Yuxiang Li, Nianshuang Zhu, Yin Int J Mol Sci Review The pancreas represents an important organ that has not been comprehensively studied in many fields. To fill this gap, many models have been generated, and traditional models have shown good performance in addressing pancreatic-related diseases, but are increasingly struggling to keep up with the need for further research due to ethical issues, genetic heterogeneity and difficult clinical translation. The new era calls for new and more reliable research models. Therefore, organoids have been proposed as a novel model for the evaluation of pancreatic-related diseases such as pancreatic malignancy, diabetes, and pancreatic cystic fibrosis. Compared with common traditional models, including 2D cell culture and gene editing mice, organoids derived from living humans or mice cause minimal harm to the donor, raise fewer ethical concerns, and reasonably address the claims of heterogeneity, which allows for the further development of pathogenesis studies and clinical trial analysis. In this review, we analyse studies on the use of pancreatic organoids in research on pancreatic-related diseases, discuss the advantages and disadvantages, and hypothesize future trends. MDPI 2023-02-16 /pmc/articles/PMC9959977/ /pubmed/36835437 http://dx.doi.org/10.3390/ijms24044027 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Yuxiang
Li, Nianshuang
Zhu, Yin
Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases
title Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases
title_full Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases
title_fullStr Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases
title_full_unstemmed Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases
title_short Pancreatic Organoids: A Frontier Method for Investigating Pancreatic-Related Diseases
title_sort pancreatic organoids: a frontier method for investigating pancreatic-related diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959977/
https://www.ncbi.nlm.nih.gov/pubmed/36835437
http://dx.doi.org/10.3390/ijms24044027
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AT zhuyin pancreaticorganoidsafrontiermethodforinvestigatingpancreaticrelateddiseases