Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy

In this issue, Hennlein and colleagues (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204113) show that F-actin–bundling protein Plastin 3 is drastically reduced in motor neurons with spinal muscular atrophy, whereas virus-mediated overexpression of Plastin 3 restores actin cytoskeleton and pro...

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Detalles Bibliográficos
Autores principales: Ramsey, Arren, Huang, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960025/
https://www.ncbi.nlm.nih.gov/pubmed/36786833
http://dx.doi.org/10.1083/jcb.202301036
Descripción
Sumario:In this issue, Hennlein and colleagues (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204113) show that F-actin–bundling protein Plastin 3 is drastically reduced in motor neurons with spinal muscular atrophy, whereas virus-mediated overexpression of Plastin 3 restores actin cytoskeleton and promotes BDNF–TrkB signaling in the growth cones of spinal motor neurons.

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