Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy

In this issue, Hennlein and colleagues (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204113) show that F-actin–bundling protein Plastin 3 is drastically reduced in motor neurons with spinal muscular atrophy, whereas virus-mediated overexpression of Plastin 3 restores actin cytoskeleton and pro...

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Detalles Bibliográficos
Autores principales: Ramsey, Arren, Huang, Eric J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960025/
https://www.ncbi.nlm.nih.gov/pubmed/36786833
http://dx.doi.org/10.1083/jcb.202301036
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author Ramsey, Arren
Huang, Eric J.
author_facet Ramsey, Arren
Huang, Eric J.
author_sort Ramsey, Arren
collection PubMed
description In this issue, Hennlein and colleagues (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204113) show that F-actin–bundling protein Plastin 3 is drastically reduced in motor neurons with spinal muscular atrophy, whereas virus-mediated overexpression of Plastin 3 restores actin cytoskeleton and promotes BDNF–TrkB signaling in the growth cones of spinal motor neurons.
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spelling pubmed-99600252023-08-14 Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy Ramsey, Arren Huang, Eric J. J Cell Biol Spotlight In this issue, Hennlein and colleagues (2023. J. Cell Biol. https://doi.org/10.1083/jcb.202204113) show that F-actin–bundling protein Plastin 3 is drastically reduced in motor neurons with spinal muscular atrophy, whereas virus-mediated overexpression of Plastin 3 restores actin cytoskeleton and promotes BDNF–TrkB signaling in the growth cones of spinal motor neurons. Rockefeller University Press 2023-02-14 /pmc/articles/PMC9960025/ /pubmed/36786833 http://dx.doi.org/10.1083/jcb.202301036 Text en © 2023 Ramsey and Huang https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Spotlight
Ramsey, Arren
Huang, Eric J.
Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy
title Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy
title_full Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy
title_fullStr Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy
title_full_unstemmed Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy
title_short Plastin 3 rescues BDNF-TrkB signaling in spinal muscular atrophy
title_sort plastin 3 rescues bdnf-trkb signaling in spinal muscular atrophy
topic Spotlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960025/
https://www.ncbi.nlm.nih.gov/pubmed/36786833
http://dx.doi.org/10.1083/jcb.202301036
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