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Quality control ensures fidelity in ribosome assembly and cellular health

The coordinated integration of ribosomal RNA and protein into two functional ribosomal subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly assembled and functional before they engage in translation. Quality control is critical in maintaining the integrity of ri...

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Detalles Bibliográficos
Autores principales: Parker, Melissa D., Karbstein, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960125/
https://www.ncbi.nlm.nih.gov/pubmed/36790396
http://dx.doi.org/10.1083/jcb.202209115
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author Parker, Melissa D.
Karbstein, Katrin
author_facet Parker, Melissa D.
Karbstein, Katrin
author_sort Parker, Melissa D.
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description The coordinated integration of ribosomal RNA and protein into two functional ribosomal subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly assembled and functional before they engage in translation. Quality control is critical in maintaining the integrity of ribosomes and necessary to support healthy cell growth and prevent diseases associated with mistakes in ribosome assembly. Its importance is demonstrated by the finding that bypassing quality control leads to misassembled, malfunctioning ribosomes with altered translation fidelity, which change gene expression and disrupt protein homeostasis. In this review, we outline our understanding of quality control within ribosome synthesis and how failure to enforce quality control contributes to human disease. We first provide a definition of quality control to guide our investigation, briefly present the main assembly steps, and then examine stages of assembly that test ribosome function, establish a pass–fail system to evaluate these functions, and contribute to altered ribosome performance when bypassed, and are thus considered “quality control.”
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spelling pubmed-99601252023-02-26 Quality control ensures fidelity in ribosome assembly and cellular health Parker, Melissa D. Karbstein, Katrin J Cell Biol Review The coordinated integration of ribosomal RNA and protein into two functional ribosomal subunits is safeguarded by quality control checkpoints that ensure ribosomes are correctly assembled and functional before they engage in translation. Quality control is critical in maintaining the integrity of ribosomes and necessary to support healthy cell growth and prevent diseases associated with mistakes in ribosome assembly. Its importance is demonstrated by the finding that bypassing quality control leads to misassembled, malfunctioning ribosomes with altered translation fidelity, which change gene expression and disrupt protein homeostasis. In this review, we outline our understanding of quality control within ribosome synthesis and how failure to enforce quality control contributes to human disease. We first provide a definition of quality control to guide our investigation, briefly present the main assembly steps, and then examine stages of assembly that test ribosome function, establish a pass–fail system to evaluate these functions, and contribute to altered ribosome performance when bypassed, and are thus considered “quality control.” Rockefeller University Press 2023-02-15 /pmc/articles/PMC9960125/ /pubmed/36790396 http://dx.doi.org/10.1083/jcb.202209115 Text en © 2023 Parker and Karbstein https://creativecommons.org/licenses/by/4.0/This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Parker, Melissa D.
Karbstein, Katrin
Quality control ensures fidelity in ribosome assembly and cellular health
title Quality control ensures fidelity in ribosome assembly and cellular health
title_full Quality control ensures fidelity in ribosome assembly and cellular health
title_fullStr Quality control ensures fidelity in ribosome assembly and cellular health
title_full_unstemmed Quality control ensures fidelity in ribosome assembly and cellular health
title_short Quality control ensures fidelity in ribosome assembly and cellular health
title_sort quality control ensures fidelity in ribosome assembly and cellular health
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960125/
https://www.ncbi.nlm.nih.gov/pubmed/36790396
http://dx.doi.org/10.1083/jcb.202209115
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