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Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury

BACKGROUND: Inflammation plays an important role in the development of acute kidney injury (AKI). However, there are few studies exploring the prognostic influence of C-reactive protein to albumin ratio (CAR) among AKI patients. In this study, we investigated whether CAR could be a useful marker to...

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Autores principales: Liu, Baohua, Lv, Dezhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960151/
https://www.ncbi.nlm.nih.gov/pubmed/36829136
http://dx.doi.org/10.1186/s12882-023-03090-9
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author Liu, Baohua
Lv, Dezhao
author_facet Liu, Baohua
Lv, Dezhao
author_sort Liu, Baohua
collection PubMed
description BACKGROUND: Inflammation plays an important role in the development of acute kidney injury (AKI). However, there are few studies exploring the prognostic influence of C-reactive protein to albumin ratio (CAR) among AKI patients. In this study, we investigated whether CAR could be a useful marker to predict the mortality of AKI. METHODS: A total of 358 AKI patients were extracted from the Medical Information Mart for Intensive Care III (MIMIC III) database. C-reactive protein (CRP) and albumin were measured at ICU admission. The clinical outcome was 365-day mortality. Cox proportional hazards model and Kaplan-Meier survival analysis were conducted to evaluate the association between CAR and outcome. RESULTS: Compared with patients in the survival group, nonsurvivors had higher CAR levels. The area under the receiver operating characteristic (ROC) curve of CAR was higher than that of CRP and albumin for mortality (0.64 vs. 0.63, 0.59, respectively). The cut-off point of CAR for mortality was 7.23. In Cox proportional-hazard regression analysis, CAR (hazards ratio (HR) =2.04, 95% confidence interval (CI) =1.47-2.85, p < 0.001 for higher CAR) and Simplified Acute Physiology Score II (HR = 1.02, 95%CI = 1.00-1.03, p = 0.004) were independent predictors of 365-day mortality. CONCLUSIONS: Our study demonstrated that a higher level of CAR was associated with 365-day mortality in AKI patients.
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spelling pubmed-99601512023-02-26 Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury Liu, Baohua Lv, Dezhao BMC Nephrol Research Article BACKGROUND: Inflammation plays an important role in the development of acute kidney injury (AKI). However, there are few studies exploring the prognostic influence of C-reactive protein to albumin ratio (CAR) among AKI patients. In this study, we investigated whether CAR could be a useful marker to predict the mortality of AKI. METHODS: A total of 358 AKI patients were extracted from the Medical Information Mart for Intensive Care III (MIMIC III) database. C-reactive protein (CRP) and albumin were measured at ICU admission. The clinical outcome was 365-day mortality. Cox proportional hazards model and Kaplan-Meier survival analysis were conducted to evaluate the association between CAR and outcome. RESULTS: Compared with patients in the survival group, nonsurvivors had higher CAR levels. The area under the receiver operating characteristic (ROC) curve of CAR was higher than that of CRP and albumin for mortality (0.64 vs. 0.63, 0.59, respectively). The cut-off point of CAR for mortality was 7.23. In Cox proportional-hazard regression analysis, CAR (hazards ratio (HR) =2.04, 95% confidence interval (CI) =1.47-2.85, p < 0.001 for higher CAR) and Simplified Acute Physiology Score II (HR = 1.02, 95%CI = 1.00-1.03, p = 0.004) were independent predictors of 365-day mortality. CONCLUSIONS: Our study demonstrated that a higher level of CAR was associated with 365-day mortality in AKI patients. BioMed Central 2023-02-25 /pmc/articles/PMC9960151/ /pubmed/36829136 http://dx.doi.org/10.1186/s12882-023-03090-9 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Liu, Baohua
Lv, Dezhao
Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury
title Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury
title_full Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury
title_fullStr Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury
title_full_unstemmed Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury
title_short Prognostic value of C-reactive protein to albumin ratio for mortality in acute kidney injury
title_sort prognostic value of c-reactive protein to albumin ratio for mortality in acute kidney injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960151/
https://www.ncbi.nlm.nih.gov/pubmed/36829136
http://dx.doi.org/10.1186/s12882-023-03090-9
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