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B-1 plasma cells require non-cognate CD4 T cell help to generate a unique repertoire of natural IgM

Evolutionarily conserved, “natural” (n)IgM is broadly reactive to both self and foreign antigens. Its selective deficiency leads to increases in autoimmune diseases and infections. In mice, nIgM is secreted independent of microbial exposure to bone marrow (BM) and spleen B-1 cell–derived plasma cell...

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Detalles Bibliográficos
Autores principales:	Smith, Fauna L., Savage, Hannah P., Luo, Zheng, Tipton, Christopher M., Lee, F. Eun-Hyung, Apostol, April C., Beaudin, Anna E., Lopez, Diego A., Jensen, Ingvill, Keller, Stefan, Baumgarth, Nicole
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960156/ https://www.ncbi.nlm.nih.gov/pubmed/36811605 http://dx.doi.org/10.1084/jem.20220195

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