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Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System

Photothermal therapy (PTT) is a new type of tumor treatment technology that is noninvasive, repeatable, and does not involve radiation. Owing to the lack of real-time and accurate noninvasive temperature measurement technology in current PTT surgical procedures, empirical and open-loop treatment las...

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Autores principales: Ma, Yiming, Liu, Yang, Lei, Zhigang, Qin, Zezheng, Shen, Yi, Sun, Mingjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960488/
https://www.ncbi.nlm.nih.gov/pubmed/36839875
http://dx.doi.org/10.3390/pharmaceutics15020555
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author Ma, Yiming
Liu, Yang
Lei, Zhigang
Qin, Zezheng
Shen, Yi
Sun, Mingjian
author_facet Ma, Yiming
Liu, Yang
Lei, Zhigang
Qin, Zezheng
Shen, Yi
Sun, Mingjian
author_sort Ma, Yiming
collection PubMed
description Photothermal therapy (PTT) is a new type of tumor treatment technology that is noninvasive, repeatable, and does not involve radiation. Owing to the lack of real-time and accurate noninvasive temperature measurement technology in current PTT surgical procedures, empirical and open-loop treatment laser power control mode inevitably leads to overtreatment. Thermal radiation causes irreversible damage to normal tissue around cancer tissue and seriously affects the therapeutic effect of PTT and other therapies conducted at the same time. Therefore, real-time measurement and control of the temperature and thermal damage of the therapeutic target are critical to the success of PTT. To improve the accuracy and safety of PTT, we propose a multi-wavelength photoacoustic (PA) temperature feedback based PTT method and system. PA thermometry information at different wavelengths is mutually corrected, and the therapeutic light dose is regulated in real time to accurately control the treatment temperature. The experimental results on the swine blood sample confirm that the proposed method can realize real-time temperature measurement and control of the target area with an accuracy of 0.56 °C and 0.68 °C, demonstrating its good prospects for application.
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spelling pubmed-99604882023-02-26 Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System Ma, Yiming Liu, Yang Lei, Zhigang Qin, Zezheng Shen, Yi Sun, Mingjian Pharmaceutics Article Photothermal therapy (PTT) is a new type of tumor treatment technology that is noninvasive, repeatable, and does not involve radiation. Owing to the lack of real-time and accurate noninvasive temperature measurement technology in current PTT surgical procedures, empirical and open-loop treatment laser power control mode inevitably leads to overtreatment. Thermal radiation causes irreversible damage to normal tissue around cancer tissue and seriously affects the therapeutic effect of PTT and other therapies conducted at the same time. Therefore, real-time measurement and control of the temperature and thermal damage of the therapeutic target are critical to the success of PTT. To improve the accuracy and safety of PTT, we propose a multi-wavelength photoacoustic (PA) temperature feedback based PTT method and system. PA thermometry information at different wavelengths is mutually corrected, and the therapeutic light dose is regulated in real time to accurately control the treatment temperature. The experimental results on the swine blood sample confirm that the proposed method can realize real-time temperature measurement and control of the target area with an accuracy of 0.56 °C and 0.68 °C, demonstrating its good prospects for application. MDPI 2023-02-07 /pmc/articles/PMC9960488/ /pubmed/36839875 http://dx.doi.org/10.3390/pharmaceutics15020555 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Yiming
Liu, Yang
Lei, Zhigang
Qin, Zezheng
Shen, Yi
Sun, Mingjian
Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System
title Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System
title_full Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System
title_fullStr Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System
title_full_unstemmed Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System
title_short Multi-Wavelength Photoacoustic Temperature Feedback Based Photothermal Therapy Method and System
title_sort multi-wavelength photoacoustic temperature feedback based photothermal therapy method and system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960488/
https://www.ncbi.nlm.nih.gov/pubmed/36839875
http://dx.doi.org/10.3390/pharmaceutics15020555
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