The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus

GPI-anchored proteins display very diverse biological (biochemical and immunological) functions. An in silico analysis has revealed that the genome of Aspergillus fumigatus contains 86 genes coding for putative GPI-anchored proteins (GPI-APs). Past research has demonstrated the involvement of GPI-AP...

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Autores principales: Samalova, Marketa, Flamant, Patricia, Beau, Rémi, Bromley, Mike, Moya-Nilges, Maryse, Fontaine, Thierry, Latgé, Jean-Paul, Mouyna, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960506/
https://www.ncbi.nlm.nih.gov/pubmed/36836370
http://dx.doi.org/10.3390/jof9020256
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author Samalova, Marketa
Flamant, Patricia
Beau, Rémi
Bromley, Mike
Moya-Nilges, Maryse
Fontaine, Thierry
Latgé, Jean-Paul
Mouyna, Isabelle
author_facet Samalova, Marketa
Flamant, Patricia
Beau, Rémi
Bromley, Mike
Moya-Nilges, Maryse
Fontaine, Thierry
Latgé, Jean-Paul
Mouyna, Isabelle
author_sort Samalova, Marketa
collection PubMed
description GPI-anchored proteins display very diverse biological (biochemical and immunological) functions. An in silico analysis has revealed that the genome of Aspergillus fumigatus contains 86 genes coding for putative GPI-anchored proteins (GPI-APs). Past research has demonstrated the involvement of GPI-APs in cell wall remodeling, virulence, and adhesion. We analyzed a new GPI-anchored protein called SwgA. We showed that this protein is mainly present in the Clavati of Aspergillus and is absent from yeasts and other molds. The protein, localized in the membrane of A. fumigatus, is involved in germination, growth, and morphogenesis, and is associated with nitrogen metabolism and thermosensitivity. swgA is controlled by the nitrogen regulator AreA. This current study indicates that GPI-APs have more general functions in fungal metabolism than cell wall biosynthesis.
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spelling pubmed-99605062023-02-26 The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus Samalova, Marketa Flamant, Patricia Beau, Rémi Bromley, Mike Moya-Nilges, Maryse Fontaine, Thierry Latgé, Jean-Paul Mouyna, Isabelle J Fungi (Basel) Article GPI-anchored proteins display very diverse biological (biochemical and immunological) functions. An in silico analysis has revealed that the genome of Aspergillus fumigatus contains 86 genes coding for putative GPI-anchored proteins (GPI-APs). Past research has demonstrated the involvement of GPI-APs in cell wall remodeling, virulence, and adhesion. We analyzed a new GPI-anchored protein called SwgA. We showed that this protein is mainly present in the Clavati of Aspergillus and is absent from yeasts and other molds. The protein, localized in the membrane of A. fumigatus, is involved in germination, growth, and morphogenesis, and is associated with nitrogen metabolism and thermosensitivity. swgA is controlled by the nitrogen regulator AreA. This current study indicates that GPI-APs have more general functions in fungal metabolism than cell wall biosynthesis. MDPI 2023-02-15 /pmc/articles/PMC9960506/ /pubmed/36836370 http://dx.doi.org/10.3390/jof9020256 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Samalova, Marketa
Flamant, Patricia
Beau, Rémi
Bromley, Mike
Moya-Nilges, Maryse
Fontaine, Thierry
Latgé, Jean-Paul
Mouyna, Isabelle
The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus
title The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus
title_full The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus
title_fullStr The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus
title_full_unstemmed The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus
title_short The New GPI-Anchored Protein, SwgA, Is Involved in Nitrogen Metabolism in the Pathogenic Filamentous Fungus Aspergillus fumigatus
title_sort new gpi-anchored protein, swga, is involved in nitrogen metabolism in the pathogenic filamentous fungus aspergillus fumigatus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960506/
https://www.ncbi.nlm.nih.gov/pubmed/36836370
http://dx.doi.org/10.3390/jof9020256
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