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Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk

Background and objectives: Epicardial adipose tissue density (EAD) has been associated with coronary arteries calcium score, a higher load of coronary artery disease (CAD) and plaque vulnerability. This effect can be related to endocrine and paracrine effect of molecules produced by epicardial adipo...

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Autores principales: Chiocchi, Marcello, Cavallo, Armando Ugo, Pugliese, Luca, Cesareni, Matteo, Pasquali, Daniela, Accardo, Giacomo, De Stasio, Vincenzo, Spiritigliozzi, Luigi, Benelli, Leonardo, D’Errico, Francesca, Cerimele, Cecilia, Floris, Roberto, Garaci, Francesco, Di Donna, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960536/
https://www.ncbi.nlm.nih.gov/pubmed/36837434
http://dx.doi.org/10.3390/medicina59020232
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author Chiocchi, Marcello
Cavallo, Armando Ugo
Pugliese, Luca
Cesareni, Matteo
Pasquali, Daniela
Accardo, Giacomo
De Stasio, Vincenzo
Spiritigliozzi, Luigi
Benelli, Leonardo
D’Errico, Francesca
Cerimele, Cecilia
Floris, Roberto
Garaci, Francesco
Di Donna, Carlo
author_facet Chiocchi, Marcello
Cavallo, Armando Ugo
Pugliese, Luca
Cesareni, Matteo
Pasquali, Daniela
Accardo, Giacomo
De Stasio, Vincenzo
Spiritigliozzi, Luigi
Benelli, Leonardo
D’Errico, Francesca
Cerimele, Cecilia
Floris, Roberto
Garaci, Francesco
Di Donna, Carlo
author_sort Chiocchi, Marcello
collection PubMed
description Background and objectives: Epicardial adipose tissue density (EAD) has been associated with coronary arteries calcium score, a higher load of coronary artery disease (CAD) and plaque vulnerability. This effect can be related to endocrine and paracrine effect of molecules produced by epicardial adipose tissue (EAT), that may influence myocardial contractility. Using coronary computed tomography angiography (CCT) the evaluation of EAD is possible in basal scans. The aim of the study is to investigate possible associations between EAD and cardiac function. Material and Methods: 93 consecutive patients undergoing CCT without and with contrast medium for known or suspected coronary CAD were evaluated. EAD was measured on basal scans, at the level of the coronary ostia, the lateral free wall of the left ventricle, at the level of the cardiac apex, and at the origin of the posterior interventricular artery. Cardiac function was evaluated in post-contrast CT scans in order to calculate ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV). Results: A statistically significant positive correlation between EAD and ejection fraction (r = 0.29, p-value < 0.01) was found. Additionally, a statistically significant negative correlation between EAD and ESV (r = −0.25, p-value < 0.01) was present. Conclusion: EAD could be considered a new risk factor associated with reduced cardiac function. The evaluation of this parameter with cardiac CT in patients with low to intermediate cardiovascular risk is possible.
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spelling pubmed-99605362023-02-26 Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk Chiocchi, Marcello Cavallo, Armando Ugo Pugliese, Luca Cesareni, Matteo Pasquali, Daniela Accardo, Giacomo De Stasio, Vincenzo Spiritigliozzi, Luigi Benelli, Leonardo D’Errico, Francesca Cerimele, Cecilia Floris, Roberto Garaci, Francesco Di Donna, Carlo Medicina (Kaunas) Article Background and objectives: Epicardial adipose tissue density (EAD) has been associated with coronary arteries calcium score, a higher load of coronary artery disease (CAD) and plaque vulnerability. This effect can be related to endocrine and paracrine effect of molecules produced by epicardial adipose tissue (EAT), that may influence myocardial contractility. Using coronary computed tomography angiography (CCT) the evaluation of EAD is possible in basal scans. The aim of the study is to investigate possible associations between EAD and cardiac function. Material and Methods: 93 consecutive patients undergoing CCT without and with contrast medium for known or suspected coronary CAD were evaluated. EAD was measured on basal scans, at the level of the coronary ostia, the lateral free wall of the left ventricle, at the level of the cardiac apex, and at the origin of the posterior interventricular artery. Cardiac function was evaluated in post-contrast CT scans in order to calculate ejection fraction (EF), end-diastolic volume (EDV), end-systolic volume (ESV), and stroke volume (SV). Results: A statistically significant positive correlation between EAD and ejection fraction (r = 0.29, p-value < 0.01) was found. Additionally, a statistically significant negative correlation between EAD and ESV (r = −0.25, p-value < 0.01) was present. Conclusion: EAD could be considered a new risk factor associated with reduced cardiac function. The evaluation of this parameter with cardiac CT in patients with low to intermediate cardiovascular risk is possible. MDPI 2023-01-26 /pmc/articles/PMC9960536/ /pubmed/36837434 http://dx.doi.org/10.3390/medicina59020232 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chiocchi, Marcello
Cavallo, Armando Ugo
Pugliese, Luca
Cesareni, Matteo
Pasquali, Daniela
Accardo, Giacomo
De Stasio, Vincenzo
Spiritigliozzi, Luigi
Benelli, Leonardo
D’Errico, Francesca
Cerimele, Cecilia
Floris, Roberto
Garaci, Francesco
Di Donna, Carlo
Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk
title Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk
title_full Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk
title_fullStr Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk
title_full_unstemmed Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk
title_short Cardiac Computed Tomography Evaluation of Association of Left Ventricle Disfunction and Epicardial Adipose Tissue Density in Patients with Low to Intermediate Cardiovascular Risk
title_sort cardiac computed tomography evaluation of association of left ventricle disfunction and epicardial adipose tissue density in patients with low to intermediate cardiovascular risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960536/
https://www.ncbi.nlm.nih.gov/pubmed/36837434
http://dx.doi.org/10.3390/medicina59020232
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