The Gut Microbiome and Metastatic Renal Cell Carcinoma

The introduction of targeted therapy (TT) and immuno-oncology (IO) agents have revolutionized the treatment of metastatic renal cell carcinoma (mRCC). However, despite the significant improvements in survival and clinical response yielded by these agents, a significant percentage of patients still e...

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Autores principales: Meza, Luis, Feng, Matthew, Lee, Kyle, Sperandio, Rubens, Pal, Sumanta Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960560/
https://www.ncbi.nlm.nih.gov/pubmed/36836036
http://dx.doi.org/10.3390/jcm12041502
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author Meza, Luis
Feng, Matthew
Lee, Kyle
Sperandio, Rubens
Pal, Sumanta Kumar
author_facet Meza, Luis
Feng, Matthew
Lee, Kyle
Sperandio, Rubens
Pal, Sumanta Kumar
author_sort Meza, Luis
collection PubMed
description The introduction of targeted therapy (TT) and immuno-oncology (IO) agents have revolutionized the treatment of metastatic renal cell carcinoma (mRCC). However, despite the significant improvements in survival and clinical response yielded by these agents, a significant percentage of patients still experience progressive disease. Evidence now suggests that microorganisms living in the gut (i.e., the gut microbiome) could be used as a biomarker for response and may also have utility in increasing response to these treatments. In this review, we present an overview of the role of the gut microbiome in cancer and its potential implications in the treatment of mRCC.
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spelling pubmed-99605602023-02-26 The Gut Microbiome and Metastatic Renal Cell Carcinoma Meza, Luis Feng, Matthew Lee, Kyle Sperandio, Rubens Pal, Sumanta Kumar J Clin Med Perspective The introduction of targeted therapy (TT) and immuno-oncology (IO) agents have revolutionized the treatment of metastatic renal cell carcinoma (mRCC). However, despite the significant improvements in survival and clinical response yielded by these agents, a significant percentage of patients still experience progressive disease. Evidence now suggests that microorganisms living in the gut (i.e., the gut microbiome) could be used as a biomarker for response and may also have utility in increasing response to these treatments. In this review, we present an overview of the role of the gut microbiome in cancer and its potential implications in the treatment of mRCC. MDPI 2023-02-14 /pmc/articles/PMC9960560/ /pubmed/36836036 http://dx.doi.org/10.3390/jcm12041502 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Meza, Luis
Feng, Matthew
Lee, Kyle
Sperandio, Rubens
Pal, Sumanta Kumar
The Gut Microbiome and Metastatic Renal Cell Carcinoma
title The Gut Microbiome and Metastatic Renal Cell Carcinoma
title_full The Gut Microbiome and Metastatic Renal Cell Carcinoma
title_fullStr The Gut Microbiome and Metastatic Renal Cell Carcinoma
title_full_unstemmed The Gut Microbiome and Metastatic Renal Cell Carcinoma
title_short The Gut Microbiome and Metastatic Renal Cell Carcinoma
title_sort gut microbiome and metastatic renal cell carcinoma
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960560/
https://www.ncbi.nlm.nih.gov/pubmed/36836036
http://dx.doi.org/10.3390/jcm12041502
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