Cargando…

Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment

Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic e...

Descripción completa

Detalles Bibliográficos
Autores principales: Escobar, Michael, Careta, Oriol, Fernández Navas, Nora, Bartkowska, Aleksandra, Alberta, Ludovico Andrea, Fornell, Jordina, Solsona, Pau, Gemming, Thomas, Gebert, Annett, Ibáñez, Elena, Blanquer, Andreu, Nogués, Carme, Sort, Jordi, Pellicer, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960669/
https://www.ncbi.nlm.nih.gov/pubmed/36826893
http://dx.doi.org/10.3390/jfb14020094
_version_ 1784895567192653824
author Escobar, Michael
Careta, Oriol
Fernández Navas, Nora
Bartkowska, Aleksandra
Alberta, Ludovico Andrea
Fornell, Jordina
Solsona, Pau
Gemming, Thomas
Gebert, Annett
Ibáñez, Elena
Blanquer, Andreu
Nogués, Carme
Sort, Jordi
Pellicer, Eva
author_facet Escobar, Michael
Careta, Oriol
Fernández Navas, Nora
Bartkowska, Aleksandra
Alberta, Ludovico Andrea
Fornell, Jordina
Solsona, Pau
Gemming, Thomas
Gebert, Annett
Ibáñez, Elena
Blanquer, Andreu
Nogués, Carme
Sort, Jordi
Pellicer, Eva
author_sort Escobar, Michael
collection PubMed
description Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −j(c), of 1.8–8.2 mA/cm(2), followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts.
format Online
Article
Text
id pubmed-9960669
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99606692023-02-26 Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment Escobar, Michael Careta, Oriol Fernández Navas, Nora Bartkowska, Aleksandra Alberta, Ludovico Andrea Fornell, Jordina Solsona, Pau Gemming, Thomas Gebert, Annett Ibáñez, Elena Blanquer, Andreu Nogués, Carme Sort, Jordi Pellicer, Eva J Funct Biomater Article Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −j(c), of 1.8–8.2 mA/cm(2), followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts. MDPI 2023-02-09 /pmc/articles/PMC9960669/ /pubmed/36826893 http://dx.doi.org/10.3390/jfb14020094 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Escobar, Michael
Careta, Oriol
Fernández Navas, Nora
Bartkowska, Aleksandra
Alberta, Ludovico Andrea
Fornell, Jordina
Solsona, Pau
Gemming, Thomas
Gebert, Annett
Ibáñez, Elena
Blanquer, Andreu
Nogués, Carme
Sort, Jordi
Pellicer, Eva
Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
title Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
title_full Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
title_fullStr Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
title_full_unstemmed Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
title_short Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
title_sort surface modified β-ti-18mo-6nb-5ta (wt%) alloy for bone implant applications: composite characterization and cytocompatibility assessment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960669/
https://www.ncbi.nlm.nih.gov/pubmed/36826893
http://dx.doi.org/10.3390/jfb14020094
work_keys_str_mv AT escobarmichael surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT caretaoriol surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT fernandeznavasnora surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT bartkowskaaleksandra surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT albertaludovicoandrea surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT fornelljordina surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT solsonapau surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT gemmingthomas surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT gebertannett surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT ibanezelena surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT blanquerandreu surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT noguescarme surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT sortjordi surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment
AT pellicereva surfacemodifiedbti18mo6nb5tawtalloyforboneimplantapplicationscompositecharacterizationandcytocompatibilityassessment