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Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment
Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic e...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960669/ https://www.ncbi.nlm.nih.gov/pubmed/36826893 http://dx.doi.org/10.3390/jfb14020094 |
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author | Escobar, Michael Careta, Oriol Fernández Navas, Nora Bartkowska, Aleksandra Alberta, Ludovico Andrea Fornell, Jordina Solsona, Pau Gemming, Thomas Gebert, Annett Ibáñez, Elena Blanquer, Andreu Nogués, Carme Sort, Jordi Pellicer, Eva |
author_facet | Escobar, Michael Careta, Oriol Fernández Navas, Nora Bartkowska, Aleksandra Alberta, Ludovico Andrea Fornell, Jordina Solsona, Pau Gemming, Thomas Gebert, Annett Ibáñez, Elena Blanquer, Andreu Nogués, Carme Sort, Jordi Pellicer, Eva |
author_sort | Escobar, Michael |
collection | PubMed |
description | Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −j(c), of 1.8–8.2 mA/cm(2), followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts. |
format | Online Article Text |
id | pubmed-9960669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99606692023-02-26 Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment Escobar, Michael Careta, Oriol Fernández Navas, Nora Bartkowska, Aleksandra Alberta, Ludovico Andrea Fornell, Jordina Solsona, Pau Gemming, Thomas Gebert, Annett Ibáñez, Elena Blanquer, Andreu Nogués, Carme Sort, Jordi Pellicer, Eva J Funct Biomater Article Commercially available titanium alloys such as Ti-6Al-4V are established in clinical use as load-bearing bone implant materials. However, concerns about the toxic effects of vanadium and aluminum have prompted the development of Al- and V-free β-Ti alloys. Herein, a new alloy composed of non-toxic elements, namely Ti-18Mo-6Nb-5Ta (wt%), has been fabricated by arc melting. The resulting single β-phase alloy shows improved mechanical properties (Young’s modulus and hardness) and similar corrosion behavior in simulated body fluid when compared with commercial Ti-6Al-4V. To increase the cell proliferation capability of the new biomaterial, the surface of Ti-18Mo-6Nb-5Ta was modified by electrodepositing calcium phosphate (CaP) ceramic layers. Coatings with a Ca/P ratio of 1.47 were obtained at pulse current densities, −j(c), of 1.8–8.2 mA/cm(2), followed by 48 h of NaOH post-treatment. The thickness of the coatings has been measured by scanning electron microscopy from an ion beam cut, resulting in an average thickness of about 5 μm. Finally, cytocompatibility and cell adhesion have been evaluated using the osteosarcoma cell line Saos-2, demonstrating good biocompatibility and enhanced cell proliferation on the CaP-modified Ti-18Mo-6Nb-5Ta material compared with the bare alloy, even outperforming their CaP-modified Ti-6-Al-4V counterparts. MDPI 2023-02-09 /pmc/articles/PMC9960669/ /pubmed/36826893 http://dx.doi.org/10.3390/jfb14020094 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Escobar, Michael Careta, Oriol Fernández Navas, Nora Bartkowska, Aleksandra Alberta, Ludovico Andrea Fornell, Jordina Solsona, Pau Gemming, Thomas Gebert, Annett Ibáñez, Elena Blanquer, Andreu Nogués, Carme Sort, Jordi Pellicer, Eva Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment |
title | Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment |
title_full | Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment |
title_fullStr | Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment |
title_full_unstemmed | Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment |
title_short | Surface Modified β-Ti-18Mo-6Nb-5Ta (wt%) Alloy for Bone Implant Applications: Composite Characterization and Cytocompatibility Assessment |
title_sort | surface modified β-ti-18mo-6nb-5ta (wt%) alloy for bone implant applications: composite characterization and cytocompatibility assessment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960669/ https://www.ncbi.nlm.nih.gov/pubmed/36826893 http://dx.doi.org/10.3390/jfb14020094 |
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