A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression

Aberrant expression of circRNAs is closely associated with the progression of gastric cancer; however, the specific mechanisms involved remain unclear. Our aim was to identify new gastric cancer biomarkers and explore the molecular mechanisms of gastric cancer progression. Therefore, we analyzed miR...

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Autores principales: Wang, Haoying, Yuan, Hao, Guo, Qinghong, Zeng, Xi, Liu, Mengxiao, Ji, Rui, Chen, Zhaofeng, Guan, Quanlin, Zheng, Ya, Wang, Yuping, Zhou, Yongning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960672/
https://www.ncbi.nlm.nih.gov/pubmed/36841760
http://dx.doi.org/10.1186/s12935-023-02871-4
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author Wang, Haoying
Yuan, Hao
Guo, Qinghong
Zeng, Xi
Liu, Mengxiao
Ji, Rui
Chen, Zhaofeng
Guan, Quanlin
Zheng, Ya
Wang, Yuping
Zhou, Yongning
author_facet Wang, Haoying
Yuan, Hao
Guo, Qinghong
Zeng, Xi
Liu, Mengxiao
Ji, Rui
Chen, Zhaofeng
Guan, Quanlin
Zheng, Ya
Wang, Yuping
Zhou, Yongning
author_sort Wang, Haoying
collection PubMed
description Aberrant expression of circRNAs is closely associated with the progression of gastric cancer; however, the specific mechanisms involved remain unclear. Our aim was to identify new gastric cancer biomarkers and explore the molecular mechanisms of gastric cancer progression. Therefore, we analyzed miRNA and circRNA microarrays of paired early-stage gastric cancer samples. Our study identified a new circRNA called hsa_circ_0069382, that had not been reported before and was expressed at low levels in gastric cancer tissues. Our study also included bioinformatics analyses which determined that the high expression of hsa_circ_0069382 regulated the BTG anti-proliferation factor 2 (BTG2)/ focal adhesion kinase (FAK) axis in gastric cancer lines by sponging for miR-15a-5p. Therefore, proliferation, invasion, and migration of gastric cancer is impacted. miR-15a-5p overexpression partially restored the effects of hsa_circ_0069382. This study provides potential new therapeutic options and a future direction to explore for gastric cancer treatment, and biomarkers. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-02871-4.
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spelling pubmed-99606722023-02-26 A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression Wang, Haoying Yuan, Hao Guo, Qinghong Zeng, Xi Liu, Mengxiao Ji, Rui Chen, Zhaofeng Guan, Quanlin Zheng, Ya Wang, Yuping Zhou, Yongning Cancer Cell Int Research Aberrant expression of circRNAs is closely associated with the progression of gastric cancer; however, the specific mechanisms involved remain unclear. Our aim was to identify new gastric cancer biomarkers and explore the molecular mechanisms of gastric cancer progression. Therefore, we analyzed miRNA and circRNA microarrays of paired early-stage gastric cancer samples. Our study identified a new circRNA called hsa_circ_0069382, that had not been reported before and was expressed at low levels in gastric cancer tissues. Our study also included bioinformatics analyses which determined that the high expression of hsa_circ_0069382 regulated the BTG anti-proliferation factor 2 (BTG2)/ focal adhesion kinase (FAK) axis in gastric cancer lines by sponging for miR-15a-5p. Therefore, proliferation, invasion, and migration of gastric cancer is impacted. miR-15a-5p overexpression partially restored the effects of hsa_circ_0069382. This study provides potential new therapeutic options and a future direction to explore for gastric cancer treatment, and biomarkers. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12935-023-02871-4. BioMed Central 2023-02-25 /pmc/articles/PMC9960672/ /pubmed/36841760 http://dx.doi.org/10.1186/s12935-023-02871-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wang, Haoying
Yuan, Hao
Guo, Qinghong
Zeng, Xi
Liu, Mengxiao
Ji, Rui
Chen, Zhaofeng
Guan, Quanlin
Zheng, Ya
Wang, Yuping
Zhou, Yongning
A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression
title A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression
title_full A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression
title_fullStr A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression
title_full_unstemmed A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression
title_short A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression
title_sort novel circrna, hsa_circ_0069382, regulates gastric cancer progression
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960672/
https://www.ncbi.nlm.nih.gov/pubmed/36841760
http://dx.doi.org/10.1186/s12935-023-02871-4
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