Functional Expression of Recombinant Candida auris Proteins in Saccharomyces cerevisiae Enables Azole Susceptibility Evaluation and Drug Discovery

Candida auris infections are difficult to treat due to acquired drug resistance against one or multiple antifungal drug classes. The most prominent resistance mechanisms in C. auris are overexpression and point mutations in Erg11, and the overexpression of efflux pump genes CDR1 and MDR1. We report...

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Detalles Bibliográficos
Autores principales: Toepfer, Stephanie, Lackner, Michaela, Keniya, Mikhail V., Monk, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960696/
https://www.ncbi.nlm.nih.gov/pubmed/36836283
http://dx.doi.org/10.3390/jof9020168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960696/
https://www.ncbi.nlm.nih.gov/pubmed/36836283
http://dx.doi.org/10.3390/jof9020168

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