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DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation

Measuring pulmonary nodules accurately can help the early diagnosis of lung cancer, which can increase the survival rate among patients. Numerous techniques for lung nodule segmentation have been developed; however, most of them either rely on the 3D volumetric region of interest (VOI) input by radi...

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Autores principales: Usman, Muhammad, Shin, Yeong-Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960760/
https://www.ncbi.nlm.nih.gov/pubmed/36850583
http://dx.doi.org/10.3390/s23041989
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author Usman, Muhammad
Shin, Yeong-Gil
author_facet Usman, Muhammad
Shin, Yeong-Gil
author_sort Usman, Muhammad
collection PubMed
description Measuring pulmonary nodules accurately can help the early diagnosis of lung cancer, which can increase the survival rate among patients. Numerous techniques for lung nodule segmentation have been developed; however, most of them either rely on the 3D volumetric region of interest (VOI) input by radiologists or use the 2D fixed region of interest (ROI) for all the slices of computed tomography (CT) scan. These methods only consider the presence of nodules within the given VOI, which limits the networks’ ability to detect nodules outside the VOI and can also encompass unnecessary structures in the VOI, leading to potentially inaccurate segmentation. In this work, we propose a novel approach for 3D lung nodule segmentation that utilizes the 2D region of interest (ROI) inputted from a radiologist or computer-aided detection (CADe) system. Concretely, we developed a two-stage lung nodule segmentation technique. Firstly, we designed a dual-encoder-based hard attention network (DEHA-Net) in which the full axial slice of thoracic computed tomography (CT) scan, along with an ROI mask, were considered as input to segment the lung nodule in the given slice. The output of DEHA-Net, the segmentation mask of the lung nodule, was inputted to the adaptive region of interest (A-ROI) algorithm to automatically generate the ROI masks for the surrounding slices, which eliminated the need for any further inputs from radiologists. After extracting the segmentation along the axial axis, at the second stage, we further investigated the lung nodule along sagittal and coronal views by employing DEHA-Net. All the estimated masks were inputted into the consensus module to obtain the final volumetric segmentation of the nodule. The proposed scheme was rigorously evaluated on the lung image database consortium and image database resource initiative (LIDC/IDRI) dataset, and an extensive analysis of the results was performed. The quantitative analysis showed that the proposed method not only improved the existing state-of-the-art methods in terms of dice score but also showed significant robustness against different types, shapes, and dimensions of the lung nodules. The proposed framework achieved the average dice score, sensitivity, and positive predictive value of 87.91%, 90.84%, and 89.56%, respectively.
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spelling pubmed-99607602023-02-26 DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation Usman, Muhammad Shin, Yeong-Gil Sensors (Basel) Article Measuring pulmonary nodules accurately can help the early diagnosis of lung cancer, which can increase the survival rate among patients. Numerous techniques for lung nodule segmentation have been developed; however, most of them either rely on the 3D volumetric region of interest (VOI) input by radiologists or use the 2D fixed region of interest (ROI) for all the slices of computed tomography (CT) scan. These methods only consider the presence of nodules within the given VOI, which limits the networks’ ability to detect nodules outside the VOI and can also encompass unnecessary structures in the VOI, leading to potentially inaccurate segmentation. In this work, we propose a novel approach for 3D lung nodule segmentation that utilizes the 2D region of interest (ROI) inputted from a radiologist or computer-aided detection (CADe) system. Concretely, we developed a two-stage lung nodule segmentation technique. Firstly, we designed a dual-encoder-based hard attention network (DEHA-Net) in which the full axial slice of thoracic computed tomography (CT) scan, along with an ROI mask, were considered as input to segment the lung nodule in the given slice. The output of DEHA-Net, the segmentation mask of the lung nodule, was inputted to the adaptive region of interest (A-ROI) algorithm to automatically generate the ROI masks for the surrounding slices, which eliminated the need for any further inputs from radiologists. After extracting the segmentation along the axial axis, at the second stage, we further investigated the lung nodule along sagittal and coronal views by employing DEHA-Net. All the estimated masks were inputted into the consensus module to obtain the final volumetric segmentation of the nodule. The proposed scheme was rigorously evaluated on the lung image database consortium and image database resource initiative (LIDC/IDRI) dataset, and an extensive analysis of the results was performed. The quantitative analysis showed that the proposed method not only improved the existing state-of-the-art methods in terms of dice score but also showed significant robustness against different types, shapes, and dimensions of the lung nodules. The proposed framework achieved the average dice score, sensitivity, and positive predictive value of 87.91%, 90.84%, and 89.56%, respectively. MDPI 2023-02-10 /pmc/articles/PMC9960760/ /pubmed/36850583 http://dx.doi.org/10.3390/s23041989 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Usman, Muhammad
Shin, Yeong-Gil
DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation
title DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation
title_full DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation
title_fullStr DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation
title_full_unstemmed DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation
title_short DEHA-Net: A Dual-Encoder-Based Hard Attention Network with an Adaptive ROI Mechanism for Lung Nodule Segmentation
title_sort deha-net: a dual-encoder-based hard attention network with an adaptive roi mechanism for lung nodule segmentation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960760/
https://www.ncbi.nlm.nih.gov/pubmed/36850583
http://dx.doi.org/10.3390/s23041989
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