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Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review

This review provides an up-to-date literature account on the efficacy of Botulinum toxin treatment for common motor disorders of Parkinson Disease. The reviewed disorders include the common motor disorders in PD such as tremor, focal foot dystonia, rigidity and freezing of gait (FOG). In the area of...

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Autores principales: Jabbari, Bahman, Comtesse, Samira Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960770/
https://www.ncbi.nlm.nih.gov/pubmed/36828396
http://dx.doi.org/10.3390/toxins15020081
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author Jabbari, Bahman
Comtesse, Samira Marie
author_facet Jabbari, Bahman
Comtesse, Samira Marie
author_sort Jabbari, Bahman
collection PubMed
description This review provides an up-to-date literature account on the efficacy of Botulinum toxin treatment for common motor disorders of Parkinson Disease. The reviewed disorders include the common motor disorders in PD such as tremor, focal foot dystonia, rigidity and freezing of gait (FOG). In the area of Parkinson tremor, two newly described evaluation/injection techniques (Yale method in USA and Western University method in Canada) offer efficacy with low incidence of hand and finger weakness as side effects. Blinded studies conducted on foot dystonia of PD indicate that botulinum toxin injections into toe flexors are efficacious in alleviating this form of dystonia. Small, blinded studies suggest improvement of Parkinson rigidity after botulinum toxin injection; proof of this claim, however, requires information from larger, blinded clinical trials. In FOG, the improvement reported in open label studies could not be substantiated in blinded investigations. However, there is room for further controlled studies that include the proximal lower limb muscles in the injection plan and/or use higher doses of the injected toxin for this indication.
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spelling pubmed-99607702023-02-26 Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review Jabbari, Bahman Comtesse, Samira Marie Toxins (Basel) Review This review provides an up-to-date literature account on the efficacy of Botulinum toxin treatment for common motor disorders of Parkinson Disease. The reviewed disorders include the common motor disorders in PD such as tremor, focal foot dystonia, rigidity and freezing of gait (FOG). In the area of Parkinson tremor, two newly described evaluation/injection techniques (Yale method in USA and Western University method in Canada) offer efficacy with low incidence of hand and finger weakness as side effects. Blinded studies conducted on foot dystonia of PD indicate that botulinum toxin injections into toe flexors are efficacious in alleviating this form of dystonia. Small, blinded studies suggest improvement of Parkinson rigidity after botulinum toxin injection; proof of this claim, however, requires information from larger, blinded clinical trials. In FOG, the improvement reported in open label studies could not be substantiated in blinded investigations. However, there is room for further controlled studies that include the proximal lower limb muscles in the injection plan and/or use higher doses of the injected toxin for this indication. MDPI 2023-01-17 /pmc/articles/PMC9960770/ /pubmed/36828396 http://dx.doi.org/10.3390/toxins15020081 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jabbari, Bahman
Comtesse, Samira Marie
Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review
title Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review
title_full Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review
title_fullStr Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review
title_full_unstemmed Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review
title_short Botulinum Toxin Treatment of Motor Disorders in Parkinson Disease—A Systematic Review
title_sort botulinum toxin treatment of motor disorders in parkinson disease—a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960770/
https://www.ncbi.nlm.nih.gov/pubmed/36828396
http://dx.doi.org/10.3390/toxins15020081
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