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Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes

Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes and may be associated with language deficits. Resting-state functional magnetic resonance imaging (fMRI) data were collected from a total of 78 children: 52 patients with BECTS (28 dru...

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Autores principales: Yang, Fei, Tan, Juan, Huang, Yue, Xiao, Ruhui, Wang, Xiaoming, Han, Yanbing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960797/
https://www.ncbi.nlm.nih.gov/pubmed/36836947
http://dx.doi.org/10.3390/life13020590
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author Yang, Fei
Tan, Juan
Huang, Yue
Xiao, Ruhui
Wang, Xiaoming
Han, Yanbing
author_facet Yang, Fei
Tan, Juan
Huang, Yue
Xiao, Ruhui
Wang, Xiaoming
Han, Yanbing
author_sort Yang, Fei
collection PubMed
description Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes and may be associated with language deficits. Resting-state functional magnetic resonance imaging (fMRI) data were collected from a total of 78 children: 52 patients with BECTS (28 drug-naïve and 24 medicated) and 26 healthy controls (HC). Granger causality analysis (GCA) was used to investigate alterations in effective connectivity (EC) between the language network core node (Broca’s area) and the whole brain. EC from Broca’s area to the left Heschl’s gyrus (HG), right putamen, and anterior cingulate cortex (ACC) was significantly increased, while EC from the bilateral putamen and left ACC to Broca’s area was significantly decreased in BECTS. Moreover, altered EC of Broca’s area to the right putamen was significantly positively correlated with verbal IQ (VIQ), while altered EC of Broca’s area to the ACC showed significantly negative correlations with the frequency of seizures. Altered EC from the left putamen to Broca’s area was also significantly negatively correlated with performance IQ (PIQ) and full-scale IQ (FSIQ) in the drug-naïve group. In addition, there was a significant positive correlation between the EC of Broca’s area to the left HG and the number of seizures, as well as between the EC of Broca’s area to the right putamen and the age at onset in the medicated group. These findings suggest abnormal causal effects on the language network related to Broca’s area in children with BECTS. Longitudinal investigation of language network development and further follow-up may be needed to illuminate the changes in organization and rebalancing over time.
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spelling pubmed-99607972023-02-26 Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes Yang, Fei Tan, Juan Huang, Yue Xiao, Ruhui Wang, Xiaoming Han, Yanbing Life (Basel) Article Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes and may be associated with language deficits. Resting-state functional magnetic resonance imaging (fMRI) data were collected from a total of 78 children: 52 patients with BECTS (28 drug-naïve and 24 medicated) and 26 healthy controls (HC). Granger causality analysis (GCA) was used to investigate alterations in effective connectivity (EC) between the language network core node (Broca’s area) and the whole brain. EC from Broca’s area to the left Heschl’s gyrus (HG), right putamen, and anterior cingulate cortex (ACC) was significantly increased, while EC from the bilateral putamen and left ACC to Broca’s area was significantly decreased in BECTS. Moreover, altered EC of Broca’s area to the right putamen was significantly positively correlated with verbal IQ (VIQ), while altered EC of Broca’s area to the ACC showed significantly negative correlations with the frequency of seizures. Altered EC from the left putamen to Broca’s area was also significantly negatively correlated with performance IQ (PIQ) and full-scale IQ (FSIQ) in the drug-naïve group. In addition, there was a significant positive correlation between the EC of Broca’s area to the left HG and the number of seizures, as well as between the EC of Broca’s area to the right putamen and the age at onset in the medicated group. These findings suggest abnormal causal effects on the language network related to Broca’s area in children with BECTS. Longitudinal investigation of language network development and further follow-up may be needed to illuminate the changes in organization and rebalancing over time. MDPI 2023-02-20 /pmc/articles/PMC9960797/ /pubmed/36836947 http://dx.doi.org/10.3390/life13020590 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Fei
Tan, Juan
Huang, Yue
Xiao, Ruhui
Wang, Xiaoming
Han, Yanbing
Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes
title Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes
title_full Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes
title_fullStr Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes
title_full_unstemmed Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes
title_short Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes
title_sort altered language-related effective connectivity in patients with benign childhood epilepsy with centrotemporal spikes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960797/
https://www.ncbi.nlm.nih.gov/pubmed/36836947
http://dx.doi.org/10.3390/life13020590
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