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Targeting Mitochondria to Control Ageing and Senescence

Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namely, mitochondrial dysfunction and cellular senescen...

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Detalles Bibliográficos
Autores principales: Protasoni, Margherita, Serrano, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960816/
https://www.ncbi.nlm.nih.gov/pubmed/36839673
http://dx.doi.org/10.3390/pharmaceutics15020352
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author Protasoni, Margherita
Serrano, Manuel
author_facet Protasoni, Margherita
Serrano, Manuel
author_sort Protasoni, Margherita
collection PubMed
description Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namely, mitochondrial dysfunction and cellular senescence. The targeting of specific mitochondrial features in senescent cells has the potential of delaying or even reverting the ageing process. A deeper and more comprehensive understanding of mitochondrial biology in senescent cells is necessary to effectively face this challenge. Here, we discuss the main alterations in mitochondrial functions and structure in both ageing and cellular senescence, highlighting the differences and similarities between the two processes. Moreover, we describe the treatments available to target these pathways and speculate on possible future directions of anti-ageing and anti-senescence therapies targeting mitochondria.
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spelling pubmed-99608162023-02-26 Targeting Mitochondria to Control Ageing and Senescence Protasoni, Margherita Serrano, Manuel Pharmaceutics Review Ageing is accompanied by a progressive impairment of cellular function and a systemic deterioration of tissues and organs, resulting in increased vulnerability to multiple diseases. Here, we review the interplay between two hallmarks of ageing, namely, mitochondrial dysfunction and cellular senescence. The targeting of specific mitochondrial features in senescent cells has the potential of delaying or even reverting the ageing process. A deeper and more comprehensive understanding of mitochondrial biology in senescent cells is necessary to effectively face this challenge. Here, we discuss the main alterations in mitochondrial functions and structure in both ageing and cellular senescence, highlighting the differences and similarities between the two processes. Moreover, we describe the treatments available to target these pathways and speculate on possible future directions of anti-ageing and anti-senescence therapies targeting mitochondria. MDPI 2023-01-20 /pmc/articles/PMC9960816/ /pubmed/36839673 http://dx.doi.org/10.3390/pharmaceutics15020352 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Protasoni, Margherita
Serrano, Manuel
Targeting Mitochondria to Control Ageing and Senescence
title Targeting Mitochondria to Control Ageing and Senescence
title_full Targeting Mitochondria to Control Ageing and Senescence
title_fullStr Targeting Mitochondria to Control Ageing and Senescence
title_full_unstemmed Targeting Mitochondria to Control Ageing and Senescence
title_short Targeting Mitochondria to Control Ageing and Senescence
title_sort targeting mitochondria to control ageing and senescence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960816/
https://www.ncbi.nlm.nih.gov/pubmed/36839673
http://dx.doi.org/10.3390/pharmaceutics15020352
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