Cloning and Characterization of Trypanosoma congolense and T. vivax Nucleoside Transporters Reveal the Potential of P1-Type Carriers for the Discovery of Broad-Spectrum Nucleoside-Based Therapeutics against Animal African Trypanosomiasis

African Animal Trypanosomiasis (AAT), caused predominantly by Trypanosoma brucei brucei, T. vivax and T. congolense, is a fatal livestock disease throughout Sub-Saharan Africa. Treatment options are very limited and threatened by resistance. Tubercidin (7-deazaadenosine) analogs have shown activity...

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Detalles Bibliográficos
Autores principales: Ungogo, Marzuq A., Aldfer, Mustafa M., Natto, Manal J., Zhuang, Hainan, Chisholm, Robyn, Walsh, Katy, McGee, MarieClaire, Ilbeigi, Kayhan, Asseri, Jamal Ibrahim, Burchmore, Richard J. S., Caljon, Guy, Van Calenbergh, Serge, De Koning, Harry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960827/
https://www.ncbi.nlm.nih.gov/pubmed/36834557
http://dx.doi.org/10.3390/ijms24043144

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