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Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion
The mechanism of systemic osteoporosis caused by chronic infection is not completely clear, and there is a lack of reasonable interventions for this disease. In this study, heat-killed S. aureus (HKSA) was applied to simulate the inflammation caused by the typical clinical pathogen and to explore th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960843/ https://www.ncbi.nlm.nih.gov/pubmed/36834587 http://dx.doi.org/10.3390/ijms24043179 |
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author | Deng, Songyun Yang, Mankai Su, Jianwen Cui, Naiqian Wu, Siyuan Zhang, Guangyan Wang, Lei Hou, Yilong Chai, Yu Yu, Bin |
author_facet | Deng, Songyun Yang, Mankai Su, Jianwen Cui, Naiqian Wu, Siyuan Zhang, Guangyan Wang, Lei Hou, Yilong Chai, Yu Yu, Bin |
author_sort | Deng, Songyun |
collection | PubMed |
description | The mechanism of systemic osteoporosis caused by chronic infection is not completely clear, and there is a lack of reasonable interventions for this disease. In this study, heat-killed S. aureus (HKSA) was applied to simulate the inflammation caused by the typical clinical pathogen and to explore the mechanism of systemic bone loss caused by it. In this study, we found that the systemic application of HKSA caused bone loss in mice. Further exploration found that HKSA caused cellular senescence, telomere length shortening, and telomere dysfunction-induced foci (TIF) in limb bones. As a well-known telomerase activator, cycloastragenol (CAG) significantly alleviated HKSA-induced telomere erosion and bone loss. These results suggested that telomere erosion in bone marrow cells is a possible mechanism of HKSA-induced bone loss. CAG may protect against HKSA-induced bone loss by alleviating telomere erosion in bone marrow cells. |
format | Online Article Text |
id | pubmed-9960843 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99608432023-02-26 Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion Deng, Songyun Yang, Mankai Su, Jianwen Cui, Naiqian Wu, Siyuan Zhang, Guangyan Wang, Lei Hou, Yilong Chai, Yu Yu, Bin Int J Mol Sci Article The mechanism of systemic osteoporosis caused by chronic infection is not completely clear, and there is a lack of reasonable interventions for this disease. In this study, heat-killed S. aureus (HKSA) was applied to simulate the inflammation caused by the typical clinical pathogen and to explore the mechanism of systemic bone loss caused by it. In this study, we found that the systemic application of HKSA caused bone loss in mice. Further exploration found that HKSA caused cellular senescence, telomere length shortening, and telomere dysfunction-induced foci (TIF) in limb bones. As a well-known telomerase activator, cycloastragenol (CAG) significantly alleviated HKSA-induced telomere erosion and bone loss. These results suggested that telomere erosion in bone marrow cells is a possible mechanism of HKSA-induced bone loss. CAG may protect against HKSA-induced bone loss by alleviating telomere erosion in bone marrow cells. MDPI 2023-02-06 /pmc/articles/PMC9960843/ /pubmed/36834587 http://dx.doi.org/10.3390/ijms24043179 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Deng, Songyun Yang, Mankai Su, Jianwen Cui, Naiqian Wu, Siyuan Zhang, Guangyan Wang, Lei Hou, Yilong Chai, Yu Yu, Bin Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion |
title | Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion |
title_full | Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion |
title_fullStr | Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion |
title_full_unstemmed | Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion |
title_short | Heat-Killed Staphylococcus aureus Induces Bone Mass Loss through Telomere Erosion |
title_sort | heat-killed staphylococcus aureus induces bone mass loss through telomere erosion |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9960843/ https://www.ncbi.nlm.nih.gov/pubmed/36834587 http://dx.doi.org/10.3390/ijms24043179 |
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