Cargando…

The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study

Background and Objectives: Maintenance of a firm and long-term stable osseointegration is the primary goal of implant dentistry. Time is used to define implant failure characteristics. Early implant failure (EIF) occurs up to one year after loading. Recent studies indicated an association between pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Masri, Daya, Retzkin, Noga, Luís Scombatti de Souza, Sérgio, Slutzkey, Gil S., Tagger-Green, Nirit, Naishlos, Sarit, Chaushu, Liat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961114/
https://www.ncbi.nlm.nih.gov/pubmed/36837603
http://dx.doi.org/10.3390/medicina59020402
_version_ 1784895675305033728
author Masri, Daya
Retzkin, Noga
Luís Scombatti de Souza, Sérgio
Slutzkey, Gil S.
Tagger-Green, Nirit
Naishlos, Sarit
Chaushu, Liat
author_facet Masri, Daya
Retzkin, Noga
Luís Scombatti de Souza, Sérgio
Slutzkey, Gil S.
Tagger-Green, Nirit
Naishlos, Sarit
Chaushu, Liat
author_sort Masri, Daya
collection PubMed
description Background and Objectives: Maintenance of a firm and long-term stable osseointegration is the primary goal of implant dentistry. Time is used to define implant failure characteristics. Early implant failure (EIF) occurs up to one year after loading. Recent studies indicated an association between proton pump inhibitors (PPI) therapy and failure of osseointegration. The present study assessed whether the use of PPIs is a risk factor to EIF. Materials and methods: A retrospective cohort study including 687 patients and 2971 dental implants. The study group (PPIs users) comprised 17.3% (119) individuals and 18.7% (555) implants. The remaining cohort (82.7% (568) individuals and 81.3% (2416) implants) served as control. The information was taken from the patients’ files. The following information was collected: age, gender, physical status, systemic diseases, HbA1C values before and after implant-supported prosthesis delivery in cases of diabetes mellitus, smoking, implant location, number of implants per individual, bone augmentation, implant brand, length and width, and EIF. EIF was defined as implant removal within a period of up to 12 months from loading. Results: EIF in PPIs vs. non-PPIs users was 19.3% vs. 14.3% (p = 0.16) at patient level and 5.4% vs. 3.5% at implant level (p = 0.03). Univariate analysis yielded factors significantly associated with PPIs use, including older age, physical status of the American Society of Anesthesiology (ASA) 3, hypertension, hyperlipidemia, diabetes mellitus, osteoporosis, cardiovascular accident (CVA), location (anterior mandible), shorter and narrower implants, and higher number of implants per individual. Multivariate analysis yielded statistically significant OR of 1.91; p = 0.01 for EIF following PPIs use and 2.3; p < 0.001 for location in anterior mandible. Conclusions: Patients and their healthcare providers are advised to carefully consider the potential risks of taking PPIs prior to dental implant surgery. Further research is needed to confirm these risks and elucidate systemic and local factors that may be involved in such outcomes.
format Online
Article
Text
id pubmed-9961114
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99611142023-02-26 The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study Masri, Daya Retzkin, Noga Luís Scombatti de Souza, Sérgio Slutzkey, Gil S. Tagger-Green, Nirit Naishlos, Sarit Chaushu, Liat Medicina (Kaunas) Article Background and Objectives: Maintenance of a firm and long-term stable osseointegration is the primary goal of implant dentistry. Time is used to define implant failure characteristics. Early implant failure (EIF) occurs up to one year after loading. Recent studies indicated an association between proton pump inhibitors (PPI) therapy and failure of osseointegration. The present study assessed whether the use of PPIs is a risk factor to EIF. Materials and methods: A retrospective cohort study including 687 patients and 2971 dental implants. The study group (PPIs users) comprised 17.3% (119) individuals and 18.7% (555) implants. The remaining cohort (82.7% (568) individuals and 81.3% (2416) implants) served as control. The information was taken from the patients’ files. The following information was collected: age, gender, physical status, systemic diseases, HbA1C values before and after implant-supported prosthesis delivery in cases of diabetes mellitus, smoking, implant location, number of implants per individual, bone augmentation, implant brand, length and width, and EIF. EIF was defined as implant removal within a period of up to 12 months from loading. Results: EIF in PPIs vs. non-PPIs users was 19.3% vs. 14.3% (p = 0.16) at patient level and 5.4% vs. 3.5% at implant level (p = 0.03). Univariate analysis yielded factors significantly associated with PPIs use, including older age, physical status of the American Society of Anesthesiology (ASA) 3, hypertension, hyperlipidemia, diabetes mellitus, osteoporosis, cardiovascular accident (CVA), location (anterior mandible), shorter and narrower implants, and higher number of implants per individual. Multivariate analysis yielded statistically significant OR of 1.91; p = 0.01 for EIF following PPIs use and 2.3; p < 0.001 for location in anterior mandible. Conclusions: Patients and their healthcare providers are advised to carefully consider the potential risks of taking PPIs prior to dental implant surgery. Further research is needed to confirm these risks and elucidate systemic and local factors that may be involved in such outcomes. MDPI 2023-02-18 /pmc/articles/PMC9961114/ /pubmed/36837603 http://dx.doi.org/10.3390/medicina59020402 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Masri, Daya
Retzkin, Noga
Luís Scombatti de Souza, Sérgio
Slutzkey, Gil S.
Tagger-Green, Nirit
Naishlos, Sarit
Chaushu, Liat
The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study
title The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study
title_full The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study
title_fullStr The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study
title_full_unstemmed The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study
title_short The Effect of Proton Pump Inhibitors on Early Implant Failure A Retrospective Cohort Study
title_sort effect of proton pump inhibitors on early implant failure a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961114/
https://www.ncbi.nlm.nih.gov/pubmed/36837603
http://dx.doi.org/10.3390/medicina59020402
work_keys_str_mv AT masridaya theeffectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT retzkinnoga theeffectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT luisscombattidesouzasergio theeffectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT slutzkeygils theeffectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT taggergreennirit theeffectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT naishlossarit theeffectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT chaushuliat theeffectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT masridaya effectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT retzkinnoga effectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT luisscombattidesouzasergio effectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT slutzkeygils effectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT taggergreennirit effectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT naishlossarit effectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy
AT chaushuliat effectofprotonpumpinhibitorsonearlyimplantfailurearetrospectivecohortstudy