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Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues
RGD peptides have received a lot of attention over the two last decades, in particular to improve tumor therapy through the targeting of the αVβ3 integrin receptor. This review focuses on the molecular design of multimeric RGD compounds, as well as the design of suitable linkers for drug delivery. M...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961187/ https://www.ncbi.nlm.nih.gov/pubmed/36839846 http://dx.doi.org/10.3390/pharmaceutics15020525 |
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author | Cossu, Jordan Thoreau, Fabien Boturyn, Didier |
author_facet | Cossu, Jordan Thoreau, Fabien Boturyn, Didier |
author_sort | Cossu, Jordan |
collection | PubMed |
description | RGD peptides have received a lot of attention over the two last decades, in particular to improve tumor therapy through the targeting of the αVβ3 integrin receptor. This review focuses on the molecular design of multimeric RGD compounds, as well as the design of suitable linkers for drug delivery. Many examples of RGD–drug conjugates have been developed, and we show the importance of RGD constructs to enhance binding affinity to tumor cells, as well as their drug uptake. Further, we also highlight the use of RGD peptides as theranostic systems, promising tools offering dual modality, such as tumor diagnosis and therapy. In conclusion, we address the challenging issues, as well as ongoing and future development, in comparison with large molecules, such as monoclonal antibodies. |
format | Online Article Text |
id | pubmed-9961187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99611872023-02-26 Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues Cossu, Jordan Thoreau, Fabien Boturyn, Didier Pharmaceutics Review RGD peptides have received a lot of attention over the two last decades, in particular to improve tumor therapy through the targeting of the αVβ3 integrin receptor. This review focuses on the molecular design of multimeric RGD compounds, as well as the design of suitable linkers for drug delivery. Many examples of RGD–drug conjugates have been developed, and we show the importance of RGD constructs to enhance binding affinity to tumor cells, as well as their drug uptake. Further, we also highlight the use of RGD peptides as theranostic systems, promising tools offering dual modality, such as tumor diagnosis and therapy. In conclusion, we address the challenging issues, as well as ongoing and future development, in comparison with large molecules, such as monoclonal antibodies. MDPI 2023-02-04 /pmc/articles/PMC9961187/ /pubmed/36839846 http://dx.doi.org/10.3390/pharmaceutics15020525 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Cossu, Jordan Thoreau, Fabien Boturyn, Didier Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues |
title | Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues |
title_full | Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues |
title_fullStr | Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues |
title_full_unstemmed | Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues |
title_short | Multimeric RGD-Based Strategies for Selective Drug Delivery to Tumor Tissues |
title_sort | multimeric rgd-based strategies for selective drug delivery to tumor tissues |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961187/ https://www.ncbi.nlm.nih.gov/pubmed/36839846 http://dx.doi.org/10.3390/pharmaceutics15020525 |
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