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Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives
Three new crystal structures of 1H-benzo[d]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961232/ https://www.ncbi.nlm.nih.gov/pubmed/36834732 http://dx.doi.org/10.3390/ijms24043319 |
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author | Olczak, Andrzej Pawlak, Tomasz Kałużyńska, Sylwia Gobis, Katarzyna Korona-Głowniak, Izabela Suśniak, Katarzyna Zaborowski, Marcin Szczesio, Małgorzata |
author_facet | Olczak, Andrzej Pawlak, Tomasz Kałużyńska, Sylwia Gobis, Katarzyna Korona-Głowniak, Izabela Suśniak, Katarzyna Zaborowski, Marcin Szczesio, Małgorzata |
author_sort | Olczak, Andrzej |
collection | PubMed |
description | Three new crystal structures of 1H-benzo[d]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs. |
format | Online Article Text |
id | pubmed-9961232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99612322023-02-26 Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives Olczak, Andrzej Pawlak, Tomasz Kałużyńska, Sylwia Gobis, Katarzyna Korona-Głowniak, Izabela Suśniak, Katarzyna Zaborowski, Marcin Szczesio, Małgorzata Int J Mol Sci Article Three new crystal structures of 1H-benzo[d]imidazole derivatives were determined. In the structures of these compounds, an identical system of hydrogen bonds, C(4), was observed. Solid-state NMR was applied for testing the quality of the obtained samples. All of these compounds were tested for in vitro antibacterial activity against Gram-positive bacteria and Gram-negative bacteria, as well as antifungal activity, by checking their selectivity. ADME calculations indicate that the compounds can be tested as potential drugs. MDPI 2023-02-07 /pmc/articles/PMC9961232/ /pubmed/36834732 http://dx.doi.org/10.3390/ijms24043319 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Olczak, Andrzej Pawlak, Tomasz Kałużyńska, Sylwia Gobis, Katarzyna Korona-Głowniak, Izabela Suśniak, Katarzyna Zaborowski, Marcin Szczesio, Małgorzata Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives |
title | Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives |
title_full | Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives |
title_fullStr | Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives |
title_full_unstemmed | Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives |
title_short | Structure and Microbiological Activity of 1H-benzo[d]imidazole Derivatives |
title_sort | structure and microbiological activity of 1h-benzo[d]imidazole derivatives |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961232/ https://www.ncbi.nlm.nih.gov/pubmed/36834732 http://dx.doi.org/10.3390/ijms24043319 |
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