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Intranasal Delivery of a Silymarin Loaded Microemulsion for the Effective Treatment of Parkinson’s Disease in Rats: Formulation, Optimization, Characterization, and In Vivo Evaluation

A mucoadhesive microemulsion of lipophilic silymarin (SLMMME) was developed to treat Parkinson’s disease (PD). Optimization of the SLM microemulsion (ME) was performed using Central Composite Design (CCD). The composition of oil, surfactant, co-surfactant, and water was varied, as per the design, to...

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Detalles Bibliográficos
Autores principales:	Imran, Mohd, Almehmadi, Mazen, Alsaiari, Ahad Amer, Kamal, Mehnaz, Alshammari, Mohammed Kanan, Alzahrani, Mohammed Omar, Almaysari, Faisal Khaled, Alzahrani, Abdulrahman Omar, Elkerdasy, Ahmed Faraj, Singh, Sachin Kumar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961237/ https://www.ncbi.nlm.nih.gov/pubmed/36839940 http://dx.doi.org/10.3390/pharmaceutics15020618

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