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Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections

Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance owing to their resistant character, representing...

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Autores principales: Martins-Santana, Leonardo, Rezende, Caroline Patini, Rossi, Antonio, Martinez-Rossi, Nilce Maria, Almeida, Fausto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961291/
https://www.ncbi.nlm.nih.gov/pubmed/36839565
http://dx.doi.org/10.3390/pathogens12020293
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author Martins-Santana, Leonardo
Rezende, Caroline Patini
Rossi, Antonio
Martinez-Rossi, Nilce Maria
Almeida, Fausto
author_facet Martins-Santana, Leonardo
Rezende, Caroline Patini
Rossi, Antonio
Martinez-Rossi, Nilce Maria
Almeida, Fausto
author_sort Martins-Santana, Leonardo
collection PubMed
description Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance owing to their resistant character, representing a bottleneck in treating affected people. Resistant fungi are an emergent public health threat. The upsurge of such pathogens has led to new research toward unraveling the destructive potential evoked by these species. Some fungi—grouped into Candida, Aspergillus, and Cryptococcus—are causative agents of severe and systemic infections. They are associated with high mortality rates and have recently been described as sources of coinfection in COVID-hospitalized patients. Despite the efforts to elucidate the challenges of colonization, dissemination, and infection severity, the immunopathogenesis of fungal diseases remains a pivotal characteristic in fungal burden elimination. The struggle between the host immune system and the physiological strategies of the fungi to maintain cellular viability is complex. In this brief review, we highlight the relevance of drug resistance phenotypes in fungi of clinical significance, taking into consideration their physiopathology and how the scientific community could orchestrate their efforts to avoid fungal infection dissemination and deaths.
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spelling pubmed-99612912023-02-26 Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections Martins-Santana, Leonardo Rezende, Caroline Patini Rossi, Antonio Martinez-Rossi, Nilce Maria Almeida, Fausto Pathogens Review Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance owing to their resistant character, representing a bottleneck in treating affected people. Resistant fungi are an emergent public health threat. The upsurge of such pathogens has led to new research toward unraveling the destructive potential evoked by these species. Some fungi—grouped into Candida, Aspergillus, and Cryptococcus—are causative agents of severe and systemic infections. They are associated with high mortality rates and have recently been described as sources of coinfection in COVID-hospitalized patients. Despite the efforts to elucidate the challenges of colonization, dissemination, and infection severity, the immunopathogenesis of fungal diseases remains a pivotal characteristic in fungal burden elimination. The struggle between the host immune system and the physiological strategies of the fungi to maintain cellular viability is complex. In this brief review, we highlight the relevance of drug resistance phenotypes in fungi of clinical significance, taking into consideration their physiopathology and how the scientific community could orchestrate their efforts to avoid fungal infection dissemination and deaths. MDPI 2023-02-10 /pmc/articles/PMC9961291/ /pubmed/36839565 http://dx.doi.org/10.3390/pathogens12020293 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martins-Santana, Leonardo
Rezende, Caroline Patini
Rossi, Antonio
Martinez-Rossi, Nilce Maria
Almeida, Fausto
Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections
title Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections
title_full Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections
title_fullStr Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections
title_full_unstemmed Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections
title_short Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections
title_sort addressing microbial resistance worldwide: challenges over controlling life-threatening fungal infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961291/
https://www.ncbi.nlm.nih.gov/pubmed/36839565
http://dx.doi.org/10.3390/pathogens12020293
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