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Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections
Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance owing to their resistant character, representing...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961291/ https://www.ncbi.nlm.nih.gov/pubmed/36839565 http://dx.doi.org/10.3390/pathogens12020293 |
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author | Martins-Santana, Leonardo Rezende, Caroline Patini Rossi, Antonio Martinez-Rossi, Nilce Maria Almeida, Fausto |
author_facet | Martins-Santana, Leonardo Rezende, Caroline Patini Rossi, Antonio Martinez-Rossi, Nilce Maria Almeida, Fausto |
author_sort | Martins-Santana, Leonardo |
collection | PubMed |
description | Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance owing to their resistant character, representing a bottleneck in treating affected people. Resistant fungi are an emergent public health threat. The upsurge of such pathogens has led to new research toward unraveling the destructive potential evoked by these species. Some fungi—grouped into Candida, Aspergillus, and Cryptococcus—are causative agents of severe and systemic infections. They are associated with high mortality rates and have recently been described as sources of coinfection in COVID-hospitalized patients. Despite the efforts to elucidate the challenges of colonization, dissemination, and infection severity, the immunopathogenesis of fungal diseases remains a pivotal characteristic in fungal burden elimination. The struggle between the host immune system and the physiological strategies of the fungi to maintain cellular viability is complex. In this brief review, we highlight the relevance of drug resistance phenotypes in fungi of clinical significance, taking into consideration their physiopathology and how the scientific community could orchestrate their efforts to avoid fungal infection dissemination and deaths. |
format | Online Article Text |
id | pubmed-9961291 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99612912023-02-26 Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections Martins-Santana, Leonardo Rezende, Caroline Patini Rossi, Antonio Martinez-Rossi, Nilce Maria Almeida, Fausto Pathogens Review Fungal infections are a serious global concern because of their ability to spread and colonize host tissues in immunocompromised individuals. Such infections have been frequently reported worldwide and are currently gaining clinical research relevance owing to their resistant character, representing a bottleneck in treating affected people. Resistant fungi are an emergent public health threat. The upsurge of such pathogens has led to new research toward unraveling the destructive potential evoked by these species. Some fungi—grouped into Candida, Aspergillus, and Cryptococcus—are causative agents of severe and systemic infections. They are associated with high mortality rates and have recently been described as sources of coinfection in COVID-hospitalized patients. Despite the efforts to elucidate the challenges of colonization, dissemination, and infection severity, the immunopathogenesis of fungal diseases remains a pivotal characteristic in fungal burden elimination. The struggle between the host immune system and the physiological strategies of the fungi to maintain cellular viability is complex. In this brief review, we highlight the relevance of drug resistance phenotypes in fungi of clinical significance, taking into consideration their physiopathology and how the scientific community could orchestrate their efforts to avoid fungal infection dissemination and deaths. MDPI 2023-02-10 /pmc/articles/PMC9961291/ /pubmed/36839565 http://dx.doi.org/10.3390/pathogens12020293 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martins-Santana, Leonardo Rezende, Caroline Patini Rossi, Antonio Martinez-Rossi, Nilce Maria Almeida, Fausto Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections |
title | Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections |
title_full | Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections |
title_fullStr | Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections |
title_full_unstemmed | Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections |
title_short | Addressing Microbial Resistance Worldwide: Challenges over Controlling Life-Threatening Fungal Infections |
title_sort | addressing microbial resistance worldwide: challenges over controlling life-threatening fungal infections |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961291/ https://www.ncbi.nlm.nih.gov/pubmed/36839565 http://dx.doi.org/10.3390/pathogens12020293 |
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