Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome

Diazepam is a benzodiazepine widely prescribed for the management of patients with severe alcohol withdrawal syndrome to prevent agitation, withdrawal seizures, and delirium tremens. Despite standard dosing of diazepam, a subset of patients experience refractory withdrawal syndromes or adverse drug...

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Autores principales: Ho, Teresa T., Noble, Melissa, Tran, Bao Anh, Sunjic, Katlynd, Gupta, Sheeba Varghese, Turgeon, Jacques, Crutchley, Rustin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961427/
https://www.ncbi.nlm.nih.gov/pubmed/36836519
http://dx.doi.org/10.3390/jpm13020285
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author Ho, Teresa T.
Noble, Melissa
Tran, Bao Anh
Sunjic, Katlynd
Gupta, Sheeba Varghese
Turgeon, Jacques
Crutchley, Rustin D.
author_facet Ho, Teresa T.
Noble, Melissa
Tran, Bao Anh
Sunjic, Katlynd
Gupta, Sheeba Varghese
Turgeon, Jacques
Crutchley, Rustin D.
author_sort Ho, Teresa T.
collection PubMed
description Diazepam is a benzodiazepine widely prescribed for the management of patients with severe alcohol withdrawal syndrome to prevent agitation, withdrawal seizures, and delirium tremens. Despite standard dosing of diazepam, a subset of patients experience refractory withdrawal syndromes or adverse drug reactions, such as impaired motor coordination, dizziness, and slurred speech. The CYP2C19 and CYP3A4 enzymes play a key role in the biotransformation of diazepam. Given the highly polymorphic nature of the CYP2C19 gene, we reviewed the clinical impact of variants in the CYP2C19 gene on both the pharmacokinetics of diazepam and treatment outcomes related to the management of alcohol withdrawal syndrome.
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spelling pubmed-99614272023-02-26 Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome Ho, Teresa T. Noble, Melissa Tran, Bao Anh Sunjic, Katlynd Gupta, Sheeba Varghese Turgeon, Jacques Crutchley, Rustin D. J Pers Med Review Diazepam is a benzodiazepine widely prescribed for the management of patients with severe alcohol withdrawal syndrome to prevent agitation, withdrawal seizures, and delirium tremens. Despite standard dosing of diazepam, a subset of patients experience refractory withdrawal syndromes or adverse drug reactions, such as impaired motor coordination, dizziness, and slurred speech. The CYP2C19 and CYP3A4 enzymes play a key role in the biotransformation of diazepam. Given the highly polymorphic nature of the CYP2C19 gene, we reviewed the clinical impact of variants in the CYP2C19 gene on both the pharmacokinetics of diazepam and treatment outcomes related to the management of alcohol withdrawal syndrome. MDPI 2023-02-03 /pmc/articles/PMC9961427/ /pubmed/36836519 http://dx.doi.org/10.3390/jpm13020285 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ho, Teresa T.
Noble, Melissa
Tran, Bao Anh
Sunjic, Katlynd
Gupta, Sheeba Varghese
Turgeon, Jacques
Crutchley, Rustin D.
Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
title Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
title_full Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
title_fullStr Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
title_full_unstemmed Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
title_short Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
title_sort clinical impact of the cyp2c19 gene on diazepam for the management of alcohol withdrawal syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961427/
https://www.ncbi.nlm.nih.gov/pubmed/36836519
http://dx.doi.org/10.3390/jpm13020285
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