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Peptide Designs for Use in Caries Management: A Systematic Review

The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in...

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Autores principales: Zhang, Olivia Lili, Niu, John Yun, Yu, Ollie Yiru, Mei, May Lei, Jakubovics, Nicholas Stephen, Chu, Chun Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961499/
https://www.ncbi.nlm.nih.gov/pubmed/36835657
http://dx.doi.org/10.3390/ijms24044247
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author Zhang, Olivia Lili
Niu, John Yun
Yu, Ollie Yiru
Mei, May Lei
Jakubovics, Nicholas Stephen
Chu, Chun Hung
author_facet Zhang, Olivia Lili
Niu, John Yun
Yu, Ollie Yiru
Mei, May Lei
Jakubovics, Nicholas Stephen
Chu, Chun Hung
author_sort Zhang, Olivia Lili
collection PubMed
description The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method.
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spelling pubmed-99614992023-02-26 Peptide Designs for Use in Caries Management: A Systematic Review Zhang, Olivia Lili Niu, John Yun Yu, Ollie Yiru Mei, May Lei Jakubovics, Nicholas Stephen Chu, Chun Hung Int J Mol Sci Review The objective of this study was to review the design methods that have been used to create peptides for use in caries management. Two independent researchers systematically reviewed many in vitro studies in which peptides were designed for use in caries management. They assessed the risk of bias in the included studies. This review identified 3592 publications, of which 62 were selected. Forty-seven studies reported 57 antimicrobial peptides. Among them, 31 studies (66%, 31/47) used the template-based design method; 9 studies (19%, 9/47) used the conjugation method; and 7 studies (15%, 7/47) used other methods, such as the synthetic combinatorial technology method, the de novo design method and cyclisation. Ten studies reported mineralising peptides. Seven of these (70%, 7/10) used the template-based design method, two (20%, 2/10) used the de novo design method, and one study (10%, 1/10) used the conjugation method. In addition, five studies developed their own peptides with antimicrobial and mineralising properties. These studies used the conjugation method. Our assessment for the risk of bias in the 62 reviewed studies showed that 44 publications (71%, 44/62) had a medium risk and that 3 publications had a low risk (5%, 3/62). The two most common methods for developing peptides for use in caries management that were used in these studies were the template-based design method and the conjugation method. MDPI 2023-02-20 /pmc/articles/PMC9961499/ /pubmed/36835657 http://dx.doi.org/10.3390/ijms24044247 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Olivia Lili
Niu, John Yun
Yu, Ollie Yiru
Mei, May Lei
Jakubovics, Nicholas Stephen
Chu, Chun Hung
Peptide Designs for Use in Caries Management: A Systematic Review
title Peptide Designs for Use in Caries Management: A Systematic Review
title_full Peptide Designs for Use in Caries Management: A Systematic Review
title_fullStr Peptide Designs for Use in Caries Management: A Systematic Review
title_full_unstemmed Peptide Designs for Use in Caries Management: A Systematic Review
title_short Peptide Designs for Use in Caries Management: A Systematic Review
title_sort peptide designs for use in caries management: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961499/
https://www.ncbi.nlm.nih.gov/pubmed/36835657
http://dx.doi.org/10.3390/ijms24044247
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