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Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients

Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls...

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Autores principales: Pellicano, Chiara, Colalillo, Amalia, Cusano, Giuseppina, Palladino, Andrea, Pellegrini, Marica, Callà, Cinzia Anna Maria, Mazzuccato, Giorgia, Carnazzo, Valeria, Pignalosa, Stefano, Di Biase, Luigi, Marino, Mariapaola, Basile, Umberto, Rosato, Edoardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961548/
https://www.ncbi.nlm.nih.gov/pubmed/36836543
http://dx.doi.org/10.3390/jpm13020309
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author Pellicano, Chiara
Colalillo, Amalia
Cusano, Giuseppina
Palladino, Andrea
Pellegrini, Marica
Callà, Cinzia Anna Maria
Mazzuccato, Giorgia
Carnazzo, Valeria
Pignalosa, Stefano
Di Biase, Luigi
Marino, Mariapaola
Basile, Umberto
Rosato, Edoardo
author_facet Pellicano, Chiara
Colalillo, Amalia
Cusano, Giuseppina
Palladino, Andrea
Pellegrini, Marica
Callà, Cinzia Anna Maria
Mazzuccato, Giorgia
Carnazzo, Valeria
Pignalosa, Stefano
Di Biase, Luigi
Marino, Mariapaola
Basile, Umberto
Rosato, Edoardo
author_sort Pellicano, Chiara
collection PubMed
description Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls (HC), matched for sex and age. Serum samples were collected and measured IgG1–4 subclasses by turbidimetry. Results: SSc patients had lower median total IgG [9.88 g/l (IQR 8.18–11.42 g/l) vs. 12.09 g/l (IQR 10.24–13.54 g/l), p < 0.001], IgG1 [5.09 g/l (IQR 4.25–6.38 g/l) vs. 6.03 g/l (IQR 5.39–7.90 g/l), p < 0.001], and IgG3 [0.59 g/l (IQR 0.40–0.77 g/l) vs. 0.80 g/l (IQR 0.46–1 g/l), p < 0.05] serum levels compared to HC. The logistic regression analysis showed IgG3 as the only variable associated with the diffusing capacity of the lung for carbon monoxide (DLco) ≤60% of the predicted [OR 9.734 (CI 95%: 1.312–72.221), p < 0.05] and modified Rodnan skin score (mRSS) [OR 1.124 (CI 95%: 1.019–1.240), p < 0.05], anti-topoisomerase I [OR 0.060 (CI 95%: 0.007–0.535), p < 0.05], and IgG3 [OR 14.062 (CI 95%: 1.352–146.229), p < 0.05] as variables associated with radiological interstitial lung disease (ILD). Conclusion: SSc patients have reduced levels of total IgG and an altered IgG subclass distribution compared to HC. Moreover, SSc patients show different serum IgG subclasses profiles according to the main involvement of the disease.
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spelling pubmed-99615482023-02-26 Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients Pellicano, Chiara Colalillo, Amalia Cusano, Giuseppina Palladino, Andrea Pellegrini, Marica Callà, Cinzia Anna Maria Mazzuccato, Giorgia Carnazzo, Valeria Pignalosa, Stefano Di Biase, Luigi Marino, Mariapaola Basile, Umberto Rosato, Edoardo J Pers Med Article Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls (HC), matched for sex and age. Serum samples were collected and measured IgG1–4 subclasses by turbidimetry. Results: SSc patients had lower median total IgG [9.88 g/l (IQR 8.18–11.42 g/l) vs. 12.09 g/l (IQR 10.24–13.54 g/l), p < 0.001], IgG1 [5.09 g/l (IQR 4.25–6.38 g/l) vs. 6.03 g/l (IQR 5.39–7.90 g/l), p < 0.001], and IgG3 [0.59 g/l (IQR 0.40–0.77 g/l) vs. 0.80 g/l (IQR 0.46–1 g/l), p < 0.05] serum levels compared to HC. The logistic regression analysis showed IgG3 as the only variable associated with the diffusing capacity of the lung for carbon monoxide (DLco) ≤60% of the predicted [OR 9.734 (CI 95%: 1.312–72.221), p < 0.05] and modified Rodnan skin score (mRSS) [OR 1.124 (CI 95%: 1.019–1.240), p < 0.05], anti-topoisomerase I [OR 0.060 (CI 95%: 0.007–0.535), p < 0.05], and IgG3 [OR 14.062 (CI 95%: 1.352–146.229), p < 0.05] as variables associated with radiological interstitial lung disease (ILD). Conclusion: SSc patients have reduced levels of total IgG and an altered IgG subclass distribution compared to HC. Moreover, SSc patients show different serum IgG subclasses profiles according to the main involvement of the disease. MDPI 2023-02-10 /pmc/articles/PMC9961548/ /pubmed/36836543 http://dx.doi.org/10.3390/jpm13020309 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pellicano, Chiara
Colalillo, Amalia
Cusano, Giuseppina
Palladino, Andrea
Pellegrini, Marica
Callà, Cinzia Anna Maria
Mazzuccato, Giorgia
Carnazzo, Valeria
Pignalosa, Stefano
Di Biase, Luigi
Marino, Mariapaola
Basile, Umberto
Rosato, Edoardo
Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
title Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
title_full Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
title_fullStr Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
title_full_unstemmed Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
title_short Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
title_sort serum immunoglobulin g (igg) subclasses in a cohort of systemic sclerosis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961548/
https://www.ncbi.nlm.nih.gov/pubmed/36836543
http://dx.doi.org/10.3390/jpm13020309
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