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Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients
Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961548/ https://www.ncbi.nlm.nih.gov/pubmed/36836543 http://dx.doi.org/10.3390/jpm13020309 |
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author | Pellicano, Chiara Colalillo, Amalia Cusano, Giuseppina Palladino, Andrea Pellegrini, Marica Callà, Cinzia Anna Maria Mazzuccato, Giorgia Carnazzo, Valeria Pignalosa, Stefano Di Biase, Luigi Marino, Mariapaola Basile, Umberto Rosato, Edoardo |
author_facet | Pellicano, Chiara Colalillo, Amalia Cusano, Giuseppina Palladino, Andrea Pellegrini, Marica Callà, Cinzia Anna Maria Mazzuccato, Giorgia Carnazzo, Valeria Pignalosa, Stefano Di Biase, Luigi Marino, Mariapaola Basile, Umberto Rosato, Edoardo |
author_sort | Pellicano, Chiara |
collection | PubMed |
description | Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls (HC), matched for sex and age. Serum samples were collected and measured IgG1–4 subclasses by turbidimetry. Results: SSc patients had lower median total IgG [9.88 g/l (IQR 8.18–11.42 g/l) vs. 12.09 g/l (IQR 10.24–13.54 g/l), p < 0.001], IgG1 [5.09 g/l (IQR 4.25–6.38 g/l) vs. 6.03 g/l (IQR 5.39–7.90 g/l), p < 0.001], and IgG3 [0.59 g/l (IQR 0.40–0.77 g/l) vs. 0.80 g/l (IQR 0.46–1 g/l), p < 0.05] serum levels compared to HC. The logistic regression analysis showed IgG3 as the only variable associated with the diffusing capacity of the lung for carbon monoxide (DLco) ≤60% of the predicted [OR 9.734 (CI 95%: 1.312–72.221), p < 0.05] and modified Rodnan skin score (mRSS) [OR 1.124 (CI 95%: 1.019–1.240), p < 0.05], anti-topoisomerase I [OR 0.060 (CI 95%: 0.007–0.535), p < 0.05], and IgG3 [OR 14.062 (CI 95%: 1.352–146.229), p < 0.05] as variables associated with radiological interstitial lung disease (ILD). Conclusion: SSc patients have reduced levels of total IgG and an altered IgG subclass distribution compared to HC. Moreover, SSc patients show different serum IgG subclasses profiles according to the main involvement of the disease. |
format | Online Article Text |
id | pubmed-9961548 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99615482023-02-26 Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients Pellicano, Chiara Colalillo, Amalia Cusano, Giuseppina Palladino, Andrea Pellegrini, Marica Callà, Cinzia Anna Maria Mazzuccato, Giorgia Carnazzo, Valeria Pignalosa, Stefano Di Biase, Luigi Marino, Mariapaola Basile, Umberto Rosato, Edoardo J Pers Med Article Objectives: To assess serum immunoglobulin G (IgG) subclasses in a cohort of systemic sclerosis (SSc) patients and to evaluate the influence of IgG subclasses in the main complications of the disease. Methods: The serum level of IgG subclasses was evaluated in 67 SSc patients and 48 healthy controls (HC), matched for sex and age. Serum samples were collected and measured IgG1–4 subclasses by turbidimetry. Results: SSc patients had lower median total IgG [9.88 g/l (IQR 8.18–11.42 g/l) vs. 12.09 g/l (IQR 10.24–13.54 g/l), p < 0.001], IgG1 [5.09 g/l (IQR 4.25–6.38 g/l) vs. 6.03 g/l (IQR 5.39–7.90 g/l), p < 0.001], and IgG3 [0.59 g/l (IQR 0.40–0.77 g/l) vs. 0.80 g/l (IQR 0.46–1 g/l), p < 0.05] serum levels compared to HC. The logistic regression analysis showed IgG3 as the only variable associated with the diffusing capacity of the lung for carbon monoxide (DLco) ≤60% of the predicted [OR 9.734 (CI 95%: 1.312–72.221), p < 0.05] and modified Rodnan skin score (mRSS) [OR 1.124 (CI 95%: 1.019–1.240), p < 0.05], anti-topoisomerase I [OR 0.060 (CI 95%: 0.007–0.535), p < 0.05], and IgG3 [OR 14.062 (CI 95%: 1.352–146.229), p < 0.05] as variables associated with radiological interstitial lung disease (ILD). Conclusion: SSc patients have reduced levels of total IgG and an altered IgG subclass distribution compared to HC. Moreover, SSc patients show different serum IgG subclasses profiles according to the main involvement of the disease. MDPI 2023-02-10 /pmc/articles/PMC9961548/ /pubmed/36836543 http://dx.doi.org/10.3390/jpm13020309 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pellicano, Chiara Colalillo, Amalia Cusano, Giuseppina Palladino, Andrea Pellegrini, Marica Callà, Cinzia Anna Maria Mazzuccato, Giorgia Carnazzo, Valeria Pignalosa, Stefano Di Biase, Luigi Marino, Mariapaola Basile, Umberto Rosato, Edoardo Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients |
title | Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients |
title_full | Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients |
title_fullStr | Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients |
title_full_unstemmed | Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients |
title_short | Serum Immunoglobulin G (IgG) Subclasses in a Cohort of Systemic Sclerosis Patients |
title_sort | serum immunoglobulin g (igg) subclasses in a cohort of systemic sclerosis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961548/ https://www.ncbi.nlm.nih.gov/pubmed/36836543 http://dx.doi.org/10.3390/jpm13020309 |
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