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The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool

Currently, there is an increasing number of people with mild cognitive (MCI) impairment and dementia (D). In the present work we studied the role of tau protein, β-amyloid, LPS (lipopolysaccharide), and curli protein of elderly adults with MCI or D and the contribution of gut microbiota. Four groups...

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Autores principales: Sánchez-Tapia, Mónica, Mimenza-Alvarado, Alberto, Granados-Domínguez, Lizbeth, Flores-López, Adriana, López-Barradas, Adriana, Ortiz, Victor, Pérez-Cruz, Claudia, Sánchez-Vidal, Hilda, Hernández-Acosta, Julieta, Ávila-Funes, José Alberto, Guevara-Cruz, Martha, Tovar, Armando R., Torres, Nimbe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961602/
https://www.ncbi.nlm.nih.gov/pubmed/36839291
http://dx.doi.org/10.3390/nu15040932
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author Sánchez-Tapia, Mónica
Mimenza-Alvarado, Alberto
Granados-Domínguez, Lizbeth
Flores-López, Adriana
López-Barradas, Adriana
Ortiz, Victor
Pérez-Cruz, Claudia
Sánchez-Vidal, Hilda
Hernández-Acosta, Julieta
Ávila-Funes, José Alberto
Guevara-Cruz, Martha
Tovar, Armando R.
Torres, Nimbe
author_facet Sánchez-Tapia, Mónica
Mimenza-Alvarado, Alberto
Granados-Domínguez, Lizbeth
Flores-López, Adriana
López-Barradas, Adriana
Ortiz, Victor
Pérez-Cruz, Claudia
Sánchez-Vidal, Hilda
Hernández-Acosta, Julieta
Ávila-Funes, José Alberto
Guevara-Cruz, Martha
Tovar, Armando R.
Torres, Nimbe
author_sort Sánchez-Tapia, Mónica
collection PubMed
description Currently, there is an increasing number of people with mild cognitive (MCI) impairment and dementia (D). In the present work we studied the role of tau protein, β-amyloid, LPS (lipopolysaccharide), and curli protein of elderly adults with MCI or D and the contribution of gut microbiota. Four groups were studied: young subjects, healthy adults older than 60 years (A), elderly adults with MCI (MCI), and elderly adults with dementia (D). A preclinical study was conducted in old male Wistar rats to evaluate the impact of gut microbiota on curli protein abundance in feces and brain. The results showed that with increasing age, tau protein, β-amyloid, and LPS significantly increased in serum during MCI and D, and this was associated with an increase in the abundance of E. coli that synthesize the amyloid protein curli, that may promote the aggregation of amyloid proteins. Rats showed a clear increase in the abundance of curli protein in the brain during aging. Thus, cognitive impairment and dementia are in part due to an alteration in the gut microbiota–brain axis via increase in curli protein and LPS leading to an increase in tau and β-amyloid protein.
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spelling pubmed-99616022023-02-26 The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool Sánchez-Tapia, Mónica Mimenza-Alvarado, Alberto Granados-Domínguez, Lizbeth Flores-López, Adriana López-Barradas, Adriana Ortiz, Victor Pérez-Cruz, Claudia Sánchez-Vidal, Hilda Hernández-Acosta, Julieta Ávila-Funes, José Alberto Guevara-Cruz, Martha Tovar, Armando R. Torres, Nimbe Nutrients Article Currently, there is an increasing number of people with mild cognitive (MCI) impairment and dementia (D). In the present work we studied the role of tau protein, β-amyloid, LPS (lipopolysaccharide), and curli protein of elderly adults with MCI or D and the contribution of gut microbiota. Four groups were studied: young subjects, healthy adults older than 60 years (A), elderly adults with MCI (MCI), and elderly adults with dementia (D). A preclinical study was conducted in old male Wistar rats to evaluate the impact of gut microbiota on curli protein abundance in feces and brain. The results showed that with increasing age, tau protein, β-amyloid, and LPS significantly increased in serum during MCI and D, and this was associated with an increase in the abundance of E. coli that synthesize the amyloid protein curli, that may promote the aggregation of amyloid proteins. Rats showed a clear increase in the abundance of curli protein in the brain during aging. Thus, cognitive impairment and dementia are in part due to an alteration in the gut microbiota–brain axis via increase in curli protein and LPS leading to an increase in tau and β-amyloid protein. MDPI 2023-02-13 /pmc/articles/PMC9961602/ /pubmed/36839291 http://dx.doi.org/10.3390/nu15040932 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sánchez-Tapia, Mónica
Mimenza-Alvarado, Alberto
Granados-Domínguez, Lizbeth
Flores-López, Adriana
López-Barradas, Adriana
Ortiz, Victor
Pérez-Cruz, Claudia
Sánchez-Vidal, Hilda
Hernández-Acosta, Julieta
Ávila-Funes, José Alberto
Guevara-Cruz, Martha
Tovar, Armando R.
Torres, Nimbe
The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
title The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
title_full The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
title_fullStr The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
title_full_unstemmed The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
title_short The Gut Microbiota–Brain Axis during Aging, Mild Cognitive Impairment and Dementia: Role of Tau Protein, β-Amyloid and LPS in Serum and Curli Protein in Stool
title_sort gut microbiota–brain axis during aging, mild cognitive impairment and dementia: role of tau protein, β-amyloid and lps in serum and curli protein in stool
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961602/
https://www.ncbi.nlm.nih.gov/pubmed/36839291
http://dx.doi.org/10.3390/nu15040932
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