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Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia
Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia and respiratory morbidity. To assess whether respiratory morbidity during the first 2 years of life in infants with left-sided CDH is associated with fetal lung volume (FLV) evaluated by the observed-to-expected FLV ratio...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961622/ https://www.ncbi.nlm.nih.gov/pubmed/36836043 http://dx.doi.org/10.3390/jcm12041508 |
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author | Cerbelle, Valentine Le Duc, Kévin Lejeune, Stephanie Mur, Sébastien Lerisson, Héloise Drumez, Elodie Sfeir, Rony Bigot, Julien Verpillat, Pauline Boukhris, Riadh Vaast, Pascal Mordacq, Clémence Thumerelle, Caroline Storme, Laurent Deschildre, Antoine |
author_facet | Cerbelle, Valentine Le Duc, Kévin Lejeune, Stephanie Mur, Sébastien Lerisson, Héloise Drumez, Elodie Sfeir, Rony Bigot, Julien Verpillat, Pauline Boukhris, Riadh Vaast, Pascal Mordacq, Clémence Thumerelle, Caroline Storme, Laurent Deschildre, Antoine |
author_sort | Cerbelle, Valentine |
collection | PubMed |
description | Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia and respiratory morbidity. To assess whether respiratory morbidity during the first 2 years of life in infants with left-sided CDH is associated with fetal lung volume (FLV) evaluated by the observed-to-expected FLV ratio (o/e FLV) on antenatal magnetic resonance imaging (MRI). In this retrospective study, o/e FLV measures were collected. Respiratory morbidity in the first 2 years of life was studied according to two endpoints: treatment with inhaled corticosteroids for >3 consecutive months and hospitalization for any acute respiratory disease. The primary outcome was a favorable progression defined by the absence of either endpoint. Forty-seven patients were included. The median o/e FLV was 39% (interquartile range, 33–49). Sixteen (34%) infants were treated with inhaled corticosteroids and 13 (28%) were hospitalized. The most efficient threshold for a favorable outcome was an o/e FLV ≥ 44% with a sensitivity of 57%, specificity of 79%, negative predictive value of 56%, and positive predictive value of 80%. An o/e FLV ≥ 44% was associated with a favorable outcome in 80% of cases. These data suggest that lung volume measurement on fetal MRI may help to identify children at lower respiratory risk and improve information during pregnancy, patient characterization, decisions about treatment strategy and research, and personalized follow-up. |
format | Online Article Text |
id | pubmed-9961622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99616222023-02-26 Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia Cerbelle, Valentine Le Duc, Kévin Lejeune, Stephanie Mur, Sébastien Lerisson, Héloise Drumez, Elodie Sfeir, Rony Bigot, Julien Verpillat, Pauline Boukhris, Riadh Vaast, Pascal Mordacq, Clémence Thumerelle, Caroline Storme, Laurent Deschildre, Antoine J Clin Med Article Congenital diaphragmatic hernia (CDH) is associated with pulmonary hypoplasia and respiratory morbidity. To assess whether respiratory morbidity during the first 2 years of life in infants with left-sided CDH is associated with fetal lung volume (FLV) evaluated by the observed-to-expected FLV ratio (o/e FLV) on antenatal magnetic resonance imaging (MRI). In this retrospective study, o/e FLV measures were collected. Respiratory morbidity in the first 2 years of life was studied according to two endpoints: treatment with inhaled corticosteroids for >3 consecutive months and hospitalization for any acute respiratory disease. The primary outcome was a favorable progression defined by the absence of either endpoint. Forty-seven patients were included. The median o/e FLV was 39% (interquartile range, 33–49). Sixteen (34%) infants were treated with inhaled corticosteroids and 13 (28%) were hospitalized. The most efficient threshold for a favorable outcome was an o/e FLV ≥ 44% with a sensitivity of 57%, specificity of 79%, negative predictive value of 56%, and positive predictive value of 80%. An o/e FLV ≥ 44% was associated with a favorable outcome in 80% of cases. These data suggest that lung volume measurement on fetal MRI may help to identify children at lower respiratory risk and improve information during pregnancy, patient characterization, decisions about treatment strategy and research, and personalized follow-up. MDPI 2023-02-14 /pmc/articles/PMC9961622/ /pubmed/36836043 http://dx.doi.org/10.3390/jcm12041508 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cerbelle, Valentine Le Duc, Kévin Lejeune, Stephanie Mur, Sébastien Lerisson, Héloise Drumez, Elodie Sfeir, Rony Bigot, Julien Verpillat, Pauline Boukhris, Riadh Vaast, Pascal Mordacq, Clémence Thumerelle, Caroline Storme, Laurent Deschildre, Antoine Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia |
title | Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia |
title_full | Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia |
title_fullStr | Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia |
title_full_unstemmed | Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia |
title_short | Fetal Lung Volume Appears to Predict Respiratory Morbidity in Congenital Diaphragmatic Hernia |
title_sort | fetal lung volume appears to predict respiratory morbidity in congenital diaphragmatic hernia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961622/ https://www.ncbi.nlm.nih.gov/pubmed/36836043 http://dx.doi.org/10.3390/jcm12041508 |
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