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The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters

Advanced glycation end products (AGEs) represent an endogenously produced or exogenously derived group of compounds derived from nonenzymatic glycation. Recent experimental studies are suggesting that AGEs could play an important role in the skin’s quality and its aging process. Hence, the aim of th...

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Autores principales: Martinovic, Dinko, Tokic, Daria, Usljebrka, Mislav, Lupi-Ferandin, Slaven, Cigic, Livia, Vanjaka Rogosic, Lucija, Ercegovic, Sasa, Kontic, Mirko, Kumrić, Marko, Rusic, Doris, Vilovic, Marino, Leskur, Mateo, Bozic, Josko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961659/
https://www.ncbi.nlm.nih.gov/pubmed/36836618
http://dx.doi.org/10.3390/life13020256
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author Martinovic, Dinko
Tokic, Daria
Usljebrka, Mislav
Lupi-Ferandin, Slaven
Cigic, Livia
Vanjaka Rogosic, Lucija
Ercegovic, Sasa
Kontic, Mirko
Kumrić, Marko
Rusic, Doris
Vilovic, Marino
Leskur, Mateo
Bozic, Josko
author_facet Martinovic, Dinko
Tokic, Daria
Usljebrka, Mislav
Lupi-Ferandin, Slaven
Cigic, Livia
Vanjaka Rogosic, Lucija
Ercegovic, Sasa
Kontic, Mirko
Kumrić, Marko
Rusic, Doris
Vilovic, Marino
Leskur, Mateo
Bozic, Josko
author_sort Martinovic, Dinko
collection PubMed
description Advanced glycation end products (AGEs) represent an endogenously produced or exogenously derived group of compounds derived from nonenzymatic glycation. Recent experimental studies are suggesting that AGEs could play an important role in the skin’s quality and its aging process. Hence, the aim of this study was to clinically evaluate the AGEs and skin quality parameters across different age groups in the general population. The study included 237 participants. Melanin, erythema, hydration, friction and transepidermal water loss (TEWL) were evaluated using noninvasive probes, while AGEs were evaluated using a skin autofluorescence reader. There was a significant positive correlation between AGEs and the amount of melanin (p < 0.001), erythema (p < 0.001) and TEWL (p < 0.001), while there was a significant negative correlation between AGEs and hydration (p < 0.001) and friction (p < 0.001). After dividing the sample into three groups depending on their age, in all three groups, there was a significant positive correlation between AGEs and the melanin count (p < 0.001) and TEWL (p < 0.001), while there was a significant negative correlation between AGEs and skin hydration (p < 0.001). Multiple linear regression analysis showed that the level of AGEs as a dependent variable retained a significant association with age (p < 0.001), melanin (p < 0.001), erythema (p = 0.005) and TEWL (p < 0.001) as positive predictors. Moreover, AGEs retained a significant association with skin hydration (p < 0.001) and friction (p = 0.017) as negative predictors. These outcomes imply that AGEs could be linked with the complex physiology of the skin and its aging process.
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spelling pubmed-99616592023-02-26 The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters Martinovic, Dinko Tokic, Daria Usljebrka, Mislav Lupi-Ferandin, Slaven Cigic, Livia Vanjaka Rogosic, Lucija Ercegovic, Sasa Kontic, Mirko Kumrić, Marko Rusic, Doris Vilovic, Marino Leskur, Mateo Bozic, Josko Life (Basel) Article Advanced glycation end products (AGEs) represent an endogenously produced or exogenously derived group of compounds derived from nonenzymatic glycation. Recent experimental studies are suggesting that AGEs could play an important role in the skin’s quality and its aging process. Hence, the aim of this study was to clinically evaluate the AGEs and skin quality parameters across different age groups in the general population. The study included 237 participants. Melanin, erythema, hydration, friction and transepidermal water loss (TEWL) were evaluated using noninvasive probes, while AGEs were evaluated using a skin autofluorescence reader. There was a significant positive correlation between AGEs and the amount of melanin (p < 0.001), erythema (p < 0.001) and TEWL (p < 0.001), while there was a significant negative correlation between AGEs and hydration (p < 0.001) and friction (p < 0.001). After dividing the sample into three groups depending on their age, in all three groups, there was a significant positive correlation between AGEs and the melanin count (p < 0.001) and TEWL (p < 0.001), while there was a significant negative correlation between AGEs and skin hydration (p < 0.001). Multiple linear regression analysis showed that the level of AGEs as a dependent variable retained a significant association with age (p < 0.001), melanin (p < 0.001), erythema (p = 0.005) and TEWL (p < 0.001) as positive predictors. Moreover, AGEs retained a significant association with skin hydration (p < 0.001) and friction (p = 0.017) as negative predictors. These outcomes imply that AGEs could be linked with the complex physiology of the skin and its aging process. MDPI 2023-01-17 /pmc/articles/PMC9961659/ /pubmed/36836618 http://dx.doi.org/10.3390/life13020256 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martinovic, Dinko
Tokic, Daria
Usljebrka, Mislav
Lupi-Ferandin, Slaven
Cigic, Livia
Vanjaka Rogosic, Lucija
Ercegovic, Sasa
Kontic, Mirko
Kumrić, Marko
Rusic, Doris
Vilovic, Marino
Leskur, Mateo
Bozic, Josko
The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters
title The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters
title_full The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters
title_fullStr The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters
title_full_unstemmed The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters
title_short The Association between the Level of Advanced Glycation End Products and Objective Skin Quality Parameters
title_sort association between the level of advanced glycation end products and objective skin quality parameters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961659/
https://www.ncbi.nlm.nih.gov/pubmed/36836618
http://dx.doi.org/10.3390/life13020256
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