Cargando…

Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers

Biomarkers can provide critical information about cancer and many other diseases; therefore, developing analytical systems for recognising biomarkers is an essential direction in bioanalytical chemistry. Recently molecularly imprinted polymers (MIPs) have been applied in analytical systems to determ...

Descripción completa

Detalles Bibliográficos
Autores principales: Pilvenyte, Greta, Ratautaite, Vilma, Boguzaite, Raimonda, Ramanavicius, Arunas, Viter, Roman, Ramanavicius, Simonas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961774/
https://www.ncbi.nlm.nih.gov/pubmed/36835517
http://dx.doi.org/10.3390/ijms24044105
_version_ 1784895838019911680
author Pilvenyte, Greta
Ratautaite, Vilma
Boguzaite, Raimonda
Ramanavicius, Arunas
Viter, Roman
Ramanavicius, Simonas
author_facet Pilvenyte, Greta
Ratautaite, Vilma
Boguzaite, Raimonda
Ramanavicius, Arunas
Viter, Roman
Ramanavicius, Simonas
author_sort Pilvenyte, Greta
collection PubMed
description Biomarkers can provide critical information about cancer and many other diseases; therefore, developing analytical systems for recognising biomarkers is an essential direction in bioanalytical chemistry. Recently molecularly imprinted polymers (MIPs) have been applied in analytical systems to determine biomarkers. This article aims to an overview of MIPs used for the detection of cancer biomarkers, namely: prostate cancer (PSA), breast cancer (CA15-3, HER-2), epithelial ovarian cancer (CA-125), hepatocellular carcinoma (AFP), and small molecule cancer biomarkers (5-HIAA and neopterin). These cancer biomarkers may be found in tumours, blood, urine, faeces, or other body fluids or tissues. The determination of low concentrations of biomarkers in these complex matrices is technically challenging. The overviewed studies used MIP-based biosensors to assess natural or artificial samples such as blood, serum, plasma, or urine. Molecular imprinting technology and MIP-based sensor creation principles are outlined. Analytical signal determination methods and the nature and chemical structure of the imprinted polymers are discussed. Based on the reviewed biosensors, the results are compared, and the most suitable materials for each biomarker are discussed.
format Online
Article
Text
id pubmed-9961774
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99617742023-02-26 Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers Pilvenyte, Greta Ratautaite, Vilma Boguzaite, Raimonda Ramanavicius, Arunas Viter, Roman Ramanavicius, Simonas Int J Mol Sci Review Biomarkers can provide critical information about cancer and many other diseases; therefore, developing analytical systems for recognising biomarkers is an essential direction in bioanalytical chemistry. Recently molecularly imprinted polymers (MIPs) have been applied in analytical systems to determine biomarkers. This article aims to an overview of MIPs used for the detection of cancer biomarkers, namely: prostate cancer (PSA), breast cancer (CA15-3, HER-2), epithelial ovarian cancer (CA-125), hepatocellular carcinoma (AFP), and small molecule cancer biomarkers (5-HIAA and neopterin). These cancer biomarkers may be found in tumours, blood, urine, faeces, or other body fluids or tissues. The determination of low concentrations of biomarkers in these complex matrices is technically challenging. The overviewed studies used MIP-based biosensors to assess natural or artificial samples such as blood, serum, plasma, or urine. Molecular imprinting technology and MIP-based sensor creation principles are outlined. Analytical signal determination methods and the nature and chemical structure of the imprinted polymers are discussed. Based on the reviewed biosensors, the results are compared, and the most suitable materials for each biomarker are discussed. MDPI 2023-02-18 /pmc/articles/PMC9961774/ /pubmed/36835517 http://dx.doi.org/10.3390/ijms24044105 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pilvenyte, Greta
Ratautaite, Vilma
Boguzaite, Raimonda
Ramanavicius, Arunas
Viter, Roman
Ramanavicius, Simonas
Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers
title Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers
title_full Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers
title_fullStr Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers
title_full_unstemmed Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers
title_short Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers
title_sort molecularly imprinted polymers for the determination of cancer biomarkers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961774/
https://www.ncbi.nlm.nih.gov/pubmed/36835517
http://dx.doi.org/10.3390/ijms24044105
work_keys_str_mv AT pilvenytegreta molecularlyimprintedpolymersforthedeterminationofcancerbiomarkers
AT ratautaitevilma molecularlyimprintedpolymersforthedeterminationofcancerbiomarkers
AT boguzaiteraimonda molecularlyimprintedpolymersforthedeterminationofcancerbiomarkers
AT ramanaviciusarunas molecularlyimprintedpolymersforthedeterminationofcancerbiomarkers
AT viterroman molecularlyimprintedpolymersforthedeterminationofcancerbiomarkers
AT ramanaviciussimonas molecularlyimprintedpolymersforthedeterminationofcancerbiomarkers