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6-Phosphogluconate dehydrogenase inhibition arrests growth and induces apoptosis in gastric cancer via AMPK activation and oxidative stress

Poor outcomes in advanced gastric cancer necessitate alternative therapeutic strategies. 6-Phosphogluconate dehydrogenase (6-PGDH), an enzyme that catalyzes the decarboxylation step in the oxidative pentose phosphate pathway, has been identified as a promising therapeutic target in many cancers. In...

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Detalles Bibliográficos
Autores principales:	Chen, Cheng, Du, Pan, Zhang, Zhenguo, Bao, Di
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	De Gruyter 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961966/ https://www.ncbi.nlm.nih.gov/pubmed/36852400 http://dx.doi.org/10.1515/biol-2022-0514

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