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The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia

B-cell precursor acute lyphoblastic leukemia (ALL) is a common pediatric malignancy and patients may have significant benefits from monoclonal antibodies therapy with increased survival rates. Positive CD20 expression is identified in about half of these patients and its presence may serve as a prog...

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Autores principales: Serbanica, Andreea Nicoleta, Popa, Delia Codruta, Caruntu, Constantin, Pasca, Sergiu, Scheau, Cristian, Serbanica, Ionut Vlad, Suciu, Raluca, Tica, Valeria, Busescu, Elisa, Cima, Luminita Nicoleta, Jardan, Cerasela, Dragomir, Mihaela, Coriu, Daniel, Colita, Andrei, Colita, Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961970/
https://www.ncbi.nlm.nih.gov/pubmed/36835986
http://dx.doi.org/10.3390/jcm12041451
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author Serbanica, Andreea Nicoleta
Popa, Delia Codruta
Caruntu, Constantin
Pasca, Sergiu
Scheau, Cristian
Serbanica, Ionut Vlad
Suciu, Raluca
Tica, Valeria
Busescu, Elisa
Cima, Luminita Nicoleta
Jardan, Cerasela
Dragomir, Mihaela
Coriu, Daniel
Colita, Andrei
Colita, Anca
author_facet Serbanica, Andreea Nicoleta
Popa, Delia Codruta
Caruntu, Constantin
Pasca, Sergiu
Scheau, Cristian
Serbanica, Ionut Vlad
Suciu, Raluca
Tica, Valeria
Busescu, Elisa
Cima, Luminita Nicoleta
Jardan, Cerasela
Dragomir, Mihaela
Coriu, Daniel
Colita, Andrei
Colita, Anca
author_sort Serbanica, Andreea Nicoleta
collection PubMed
description B-cell precursor acute lyphoblastic leukemia (ALL) is a common pediatric malignancy and patients may have significant benefits from monoclonal antibodies therapy with increased survival rates. Positive CD20 expression is identified in about half of these patients and its presence may serve as a prognostic factor in disease evolution. We performed a retrospective study including 114 patients diagnosed with B-ALL and evaluated the expression of CD20 through flow cytometry at diagnosis and on day 15. Additional immunophenotypic analyses as well as cytogenetic and molecular genetic analyses were also performed. We observed an increase in the mean fluorescence intensity (MFI) of CD20 between diagnosis—1.9 (1.2–3.26) and day 15: 6.17 (2.14–27.4), (p < 0.0001). Furthermore, we assessed that both diagnosis and day 15 CD20 MFI had an impact on RFS and OS, respectively, for cut-off values of >8.08 at diagnosis and >28.65 at day 15. In conclusion, CD20 expression appears to be a poor prognostic feature of B-ALL in pediatric patients. In this study, stratification of the outcome by the intensity of CD20 has implications concerning the allocation to rituximab-based chemotherapy and may offer new, potentially useful information for pediatric patients with B-ALL.
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spelling pubmed-99619702023-02-26 The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia Serbanica, Andreea Nicoleta Popa, Delia Codruta Caruntu, Constantin Pasca, Sergiu Scheau, Cristian Serbanica, Ionut Vlad Suciu, Raluca Tica, Valeria Busescu, Elisa Cima, Luminita Nicoleta Jardan, Cerasela Dragomir, Mihaela Coriu, Daniel Colita, Andrei Colita, Anca J Clin Med Article B-cell precursor acute lyphoblastic leukemia (ALL) is a common pediatric malignancy and patients may have significant benefits from monoclonal antibodies therapy with increased survival rates. Positive CD20 expression is identified in about half of these patients and its presence may serve as a prognostic factor in disease evolution. We performed a retrospective study including 114 patients diagnosed with B-ALL and evaluated the expression of CD20 through flow cytometry at diagnosis and on day 15. Additional immunophenotypic analyses as well as cytogenetic and molecular genetic analyses were also performed. We observed an increase in the mean fluorescence intensity (MFI) of CD20 between diagnosis—1.9 (1.2–3.26) and day 15: 6.17 (2.14–27.4), (p < 0.0001). Furthermore, we assessed that both diagnosis and day 15 CD20 MFI had an impact on RFS and OS, respectively, for cut-off values of >8.08 at diagnosis and >28.65 at day 15. In conclusion, CD20 expression appears to be a poor prognostic feature of B-ALL in pediatric patients. In this study, stratification of the outcome by the intensity of CD20 has implications concerning the allocation to rituximab-based chemotherapy and may offer new, potentially useful information for pediatric patients with B-ALL. MDPI 2023-02-11 /pmc/articles/PMC9961970/ /pubmed/36835986 http://dx.doi.org/10.3390/jcm12041451 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Serbanica, Andreea Nicoleta
Popa, Delia Codruta
Caruntu, Constantin
Pasca, Sergiu
Scheau, Cristian
Serbanica, Ionut Vlad
Suciu, Raluca
Tica, Valeria
Busescu, Elisa
Cima, Luminita Nicoleta
Jardan, Cerasela
Dragomir, Mihaela
Coriu, Daniel
Colita, Andrei
Colita, Anca
The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
title The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
title_full The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
title_fullStr The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
title_full_unstemmed The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
title_short The Significance of CD20 Intensity Variance in Pediatric Patients with B-Cell Precursor Acute Lymphoblastic Leukemia
title_sort significance of cd20 intensity variance in pediatric patients with b-cell precursor acute lymphoblastic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9961970/
https://www.ncbi.nlm.nih.gov/pubmed/36835986
http://dx.doi.org/10.3390/jcm12041451
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